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Anti-aging Strategies and Topical Delivery of Biopolymer-based Nanocarriers for Skin Cancer Treatment

Jino Affrald Ramaraj1, Shoba Narayan1

  • 1Faculty of Allied Health Sciences, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Kelambakkam, Tamil Nadu, 603103, India.

Current Aging Science
|March 21, 2023
PubMed

Insights

Biopolymers can be used in topical anti-aging formulations to help prevent skin cancer. These natural compounds target key receptors involved in both aging and cancer development, offering a dual therapeutic approach.

Area of Science:

  • Dermatology and Oncology
  • Biotechnology and Aging Research

Background:

  • Environmental factors like UV radiation and epigenetic changes accelerate skin aging and contribute to skin cancer.
  • Biopolymers (polysaccharides, polyphenols, proteins, nucleic acids) are crucial for maintaining normal cell homeostasis.
  • Aging and skin cancer share common pathways and molecular targets, including specific receptors and signaling cascades.

Purpose of the Study:

  • To review the role of biopolymers in anti-aging formulations.
  • To explore the potential of topical biopolymer formulations for skin cancer prevention.
  • To identify shared therapeutic targets between aging and cancer.

Main Methods:

  • Literature review focusing on environmental factors, aging, cancer development, and biopolymers.
  • Analysis of receptor associations between aging and cancer (e.g., insulin, melatonin, toll-like, SIRT 1 receptors).
  • Examination of biopolymer-based nanoformulations and their therapeutic potential.

Main Results:

  • Biopolymers play a vital role in regulating cell homeostasis and show potential as anti-aging agents.
  • Shared receptors and pathways between aging and cancer suggest dual-targeting therapeutic strategies.
  • Biopolymer-based nanoformulations, like those containing curcumin and resveratrol, demonstrate promise in preventing both aging and cancer.

Conclusions:

  • Topical biopolymer supplements during aging may prevent skin cancer.
  • Targeting shared receptors and pathways offers a novel approach for simultaneous cancer and aging prevention.
  • Biopolymer nanoformulations represent a promising strategy for dual therapeutic intervention against skin aging and cancer.
Keywords:
Skinagingbiopolymers.cancernanoformulationreceptors

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