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[Chronic kidney disease and growth failure: Efficacy of growth hormone treatment]

Rouba Bechara1, Sylvie Rossignol1, Ariane Zaloszyc1

  • 1Pédiatrie 1, CHU de Hautepierre, Hôpitaux universitaires de Strasbourg, 67000 Strasbourg, France.

Medecine Sciences : M/S
|March 21, 2023
PubMed

Insights

Growth failure in children with chronic kidney disease (CKD) is common but manageable. Treatment involves addressing nutritional issues and using recombinant growth hormone to improve growth outcomes.

Area of Science:

  • Pediatric Nephrology
  • Endocrinology
  • Growth Disorders

Context:

  • Chronic kidney disease (CKD) frequently causes growth failure in children, increasing morbidity and mortality.
  • Achieving normal growth in pediatric CKD patients presents significant challenges for clinicians.
  • Growth failure is multifactorial, linked to impaired growth hormone (GH) sensitivity and insulin-like growth factor 1 (IGF1) deficiency.

Purpose:

  • To summarize the causes, assessment, and management of growth failure in pediatric CKD.
  • To review the role of recombinant human growth hormone (rhGH) in treating growth failure in this population.

Summary:

  • Growth failure in pediatric CKD is multifactorial, involving hormonal imbalances and metabolic derangements.
  • Management strategies include nutritional and metabolic correction, optimized dialysis, and rhGH administration.
  • rhGH is used at supraphysiologic doses to counteract GH insensitivity.

Impact:

  • Improved understanding of growth failure mechanisms in pediatric CKD.
  • Enhanced therapeutic strategies for optimizing growth in affected children.
  • Potential for reduced morbidity and mortality through effective growth management.

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