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Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
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Association between intestinal microflora and obesity.

Maryana Savytska1, Marko Kozyk2, Kateryna Strubchevska2

  • 1Department of Normal Physiology, Danylo Halytsky Lviv National Medical University, Lviv, Ukraine.

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Summary

The gut microbiota, or the collection of microbes in your intestines, plays a significant role in obesity. Alterations in gut microbial composition can impact human metabolism and weight management.

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Area of Science:

  • Microbiology
  • Metabolism
  • Obesity Research

Background:

  • Obesity is a major global health issue with rising healthcare costs.
  • Recent research links gut microbial composition to obesity development.
  • Imbalanced energy intake is a known factor in obesity.

Purpose of the Study:

  • To review current knowledge on intestinal microbiota definition, composition, and functions.
  • To explore the association between gut microbiota and obesity.
  • To discuss the role of gut microbiota in metabolic health.

Main Methods:

  • Extensive literature review.
  • Searched keywords: metabolism, gut microbiota, dysbiosis, obesity.
  • Synthesized current evidence on the topic.

Main Results:

  • A strong association exists between intestinal microbiota and obesity across all ages.
  • Gut microbial composition is implicated in the pathogenesis of obesity.
  • Changes in gut microbiota can influence human metabolism and weight.

Conclusions:

  • Gut microbial composition is a key factor in obesity development.
  • Consideration of probiotics, prebiotics, and antibiotics in obese patients is warranted.
  • Understanding gut microbiota offers potential therapeutic targets for obesity and metabolic disorders.