Effects of a high-fat diet on the bone structure of Wistar rats: a systematic review
Rafael T Silva1, Luciana J D Ferreira1, Ana P A Macêdo2
1are with the Post-Graduate Program in Food, Nutrition, and Health, Department of nutrition, Federal University of Bahia (UFBA), Salvador, Bahia, Brazil.
Context:
Saturated fats found in diets known as high-fat, cafeteria, or Western diets appear to have a negative effect on bone structure; however, few studies have focused on investigating this association, and the data available in the literature remain controversial.
Objective:
The aim of the current review was to investigate the effects of a high-fat dietary intake on the bone structure of Wistar rats.
Data Sources:
A search for articles was carried out in the Pubmed/MEDLINE, Web of Science, Embase, and Scopus databases.
Data Extraction:
In total, 447 articles were found in the initial search; 5 articles were included in the systematic review, after application of the exclusion criteria.
Data Analysis:
The review was guided by the PICOS strategy and based on the PRISMA protocol for animal reviews.
Conclusion:
High-fat diets appear to affect bone structure of Wistar rats. Diet composition and exposure time are the factors determining the strength of the effect.
More Related Videos
04:24Proper Positioning and Restraint of a Rat Hind Limb for Focused High Resolution Imaging of Bone Micro-architecture Using In Vivo Micro-computed Tomography
Published on: November 22, 2017
05:55Author Spotlight: Developing a Rat Model for Weight-Bearing Intervention to Investigate Osteonecrosis of the Femoral Head
Published on: September 27, 2024
Related Concept Videos
Bone Disorders
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone Structure
Osteoclasts in Bone Remodeling
Bone Remodeling
Essential Minerals for Bone Health
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
Role of Vitamins in Maintaining Bone Health
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
