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Related Experiment Video

Updated: Aug 6, 2025

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging
09:14

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging

Published on: March 14, 2025

275

Structural brain differences related to compulsive sexual behavior disorder.

Per Görts1, Josephine Savard1,2,3, Katarina Görts-Öberg2,3

  • 11Department of Clinical Sciences/Psychiatry, Umeå University, Umeå, Sweden.

Journal of Behavioral Addictions
|March 21, 2023
PubMed
Summary
This summary is machine-generated.

Compulsive sexual behavior disorder (CSBD) is linked to reduced surface area in the right posterior cingulate cortex. This brain difference correlates with CSBD symptom severity, offering insights into the disorder's neurobiology.

Keywords:
brain structurecompulsive sexual behaviorhypersexual disorderneuroimagingrewardsurface area

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Area of Science:

  • Neuroimaging
  • Psychiatry
  • Neurobiology

Background:

  • Compulsive sexual behavior disorder (CSBD) is recognized as an impulse control disorder in ICD-11.
  • The neurobiological underpinnings of CSBD are not well understood.
  • Previous research suggests potential addiction-like mechanisms in CSBD.

Purpose of the Study:

  • To investigate structural brain differences in individuals with CSBD.
  • To explore associations between these differences and reward processing regions.
  • To examine the relationship between brain structure and CSBD symptom severity.

Main Methods:

  • Structural MRI data from 22 male CSBD patients and 20 healthy controls were analyzed.
  • Regional cortical thickness and surface area were primary outcome measures.
  • Subcortical structures and white matter integrity were also assessed.

Main Results:

  • CSBD patients exhibited significantly lower cortical surface area in the right posterior cingulate cortex compared to controls.
  • A negative correlation was observed between right posterior cingulate cortex area and CSBD symptom severity.
  • No significant group differences were found in subcortical volumes.

Conclusions:

  • CSBD is associated with distinct structural brain alterations.
  • The right posterior cingulate cortex may play a role in the neurobiology of CSBD.
  • Further research is needed to elucidate the precise neurobiological mechanisms underlying CSBD.