Related Experiment Video
Updated: Aug 6, 2025
09:44
Neuro-rehabilitation Approach for Sudden Sensorineural Hearing Loss
Published on: January 25, 2016
19.3K
Corticosteroids for COVID-19.
1Department of Intensive Care, Hôpital Raymond Poincaré (APHP), Laboratory of Infection & Inflammation - U1173, School of Medicine Simone Veil, University Versailles Saint Quentin - University Paris Saclay, INSERM, 104 boulevard Raymond Poincaré, Garches 92380, France.
Journal of Intensive Medicine
|March 21, 2023
Summary
Corticosteroids, like dexamethasone, improve survival for patients with severe COVID-19 requiring oxygen. This treatment did not increase infection or viral clearance risks, supporting its use in clinical practice.
Area of Science:
- Immunology
- Infectious Diseases
- Pharmacology
Background:
- Coronavirus disease 19 (COVID-19) presents a significant global health challenge.
- A deregulated immune response and systemic inflammation are key factors in severe COVID-19.
- Immunomodulatory therapies are a critical research focus for managing COVID-19.
Purpose of the Study:
- To evaluate the efficacy and safety of corticosteroids in managing COVID-19 patients.
- To synthesize evidence from randomized controlled trials and meta-analyses on corticotherapy for COVID-19.
Main Methods:
- Review of numerous observational cohorts.
- Analysis of high-quality randomized controlled trials and meta-analyses.
- Assessment of corticosteroid effects on survival, need for life support, and risks of secondary infections or delayed viral clearance.
Main Results:
- Corticosteroids (e.g., 6mg/day dexamethasone) significantly increase survival chances.
- These drugs provide relief from life-supportive therapy.
- No increased risk of bacterial infection or delayed viral clearance was observed with corticotherapy.
Conclusions:
- Corticosteroids are recommended for managing COVID-19 patients requiring oxygen supplementation.
- Evidence supports the use of dexamethasone or equivalent corticosteroids to improve outcomes in severe COVID-19.
- The benefits of corticosteroids outweigh potential risks in this patient population.
More Related Videos
Related Concept Videos
01:21Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids
176
Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2...
176
01:25Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids
335
Inhaled corticosteroids (ICS) are anti-inflammatory drugs used primarily in treating persistent asthma and providing long-term maintenance. They target the bronchial mucosa, the lining of the airways, to control inflammation, a critical factor in asthma progression and exacerbation.
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
335
01:26COPD: Management Using Bronchodilators and Corticosteroids
265
Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
265
01:29Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
221
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
221
01:14Myocarditis III: Medical Management
11
Myocarditis: Comprehensive Medical ManagementMyocarditis, the heart muscle inflammation, requires a comprehensive medical management strategy that addresses the underlying cause, provides supportive care, manages symptoms, and reduces cardiac workload.Infections and Autoimmune CausesAdminister appropriate antimicrobial therapy when an infectious agent causes myocarditis. For instance, penicillin treats infections caused by Group A Streptococcus. In cases where autoimmune processes are...
11
01:17Pericarditis III: Medical Management
19
The primary objectives of managing pericarditis are to determine the underlying cause, provide effective therapy for treatment and symptom relief, and promptly detect signs and symptoms of cardiac tamponade. The following outlines the essential aspects of medical management for pericarditis:ObjectivesDetermine the Cause: Identifying the underlying cause of pericarditis is crucial for targeted treatment. Causes include viral infections, autoimmune diseases, post-cardiac injury syndrome, and...
19