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Related Experiment Video

Updated: Aug 6, 2025

A Method for Evaluating the Reinforcing Properties of Ethanol in Rats without Water Deprivation, Saccharin Fading or Extended Access Training

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Published on: January 29, 2017

An FGF21 fix to get sober.

¹Science Signaling, AAAS, Washington, DC 20005, USA.

Science Signaling

|March 21, 2023

Summary

This summary is machine-generated.

Fibroblast growth factor 21 (FGF21) activates specific brain neurons to help mice recover from alcohol intoxication. This discovery offers new insights into potential therapeutic targets for ethanol intoxication.

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Area of Science:

Neuroscience
Endocrinology
Pharmacology

Background:

Ethanol intoxication poses significant health risks.
The brain's response to alcohol and recovery mechanisms are not fully understood.
Fibroblast growth factor 21 (FGF21) is a hormone with diverse physiological effects.

Purpose of the Study:

To investigate the role of FGF21 in the recovery from ethanol intoxication.
To identify the specific neural pathways involved in FGF21's effects on alcohol intoxication.

Main Methods:

Utilized mouse models of ethanol intoxication.
Administered FGF21 and monitored behavioral recovery.
Employed techniques like neuronal tracing and in vivo calcium imaging to assess neuronal activity.

Main Results:

FGF21 administration significantly accelerated recovery from ethanol-induced impairment.
FGF21 specifically activated noradrenergic neurons in the locus coeruleus.
Direct activation of these neurons mimicked the recovery effects of FGF21.

Conclusions:

FGF21-mediated activation of noradrenergic neurons is a key mechanism for recovery from ethanol intoxication.
Targeting the FGF21-noradrenergic pathway may represent a novel therapeutic strategy for alcohol intoxication.