Controlling Nutritional Status score and postmenopausal osteoporosis.

Area of Science:

• Endocrinology
• Gerontology
• Nutritional Science

Background:

• Osteoporosis is a significant health concern for postmenopausal women.
• Nutritional status is recognized as a contributing factor to bone health.
• The Controlling Nutritional Status (CONUT) score is a validated tool for assessing nutritional status.

Purpose of the Study:

• To investigate the association between the CONUT score and postmenopausal osteoporosis.
• To evaluate the predictive value of the CONUT score for osteoporosis in postmenopausal women.

Main Methods:

• A cross-sectional study included 423 postmenopausal women, divided into osteoporosis (T-score < -2.5 SD) and normal bone density (T-score > -1 SD) groups.
• The CONUT score was calculated based on serum albumin, total cholesterol, and lymphocyte count.
• Receiver operating characteristic (ROC) curve analysis was performed to assess the predictive performance of the CONUT score.

Main Results:

• Women with osteoporosis had significantly higher CONUT scores compared to those with normal bone density (3.180 ± 1.804 vs 0.391 ± 0.687, P < 0.001).
• The CONUT score demonstrated high predictive accuracy for osteoporosis, with an area under the ROC curve of 0.932, a sensitivity of 86.6%, and a specificity of 91.1% (P < 0.001).
• Women with osteoporosis had a longer duration of menopause and lower body mass index.

Conclusions:

• The CONUT score is significantly associated with postmenopausal osteoporosis.
• The CONUT score serves as a valuable and accurate predictor of osteoporosis in postmenopausal women.
• This finding highlights the importance of nutritional assessment in managing osteoporosis risk.