Lumbar radiculopathy secondary to primary spinal dural diffuse large B-cell lymphoma

Area of Science:

• Neurology
• Oncology
• Pathology

Background:

• Primary central nervous system lymphoma (PCNSL) is rare, with dural genesis representing a distinct subtype.
• Dural lymphomas exhibit varied histology based on location: cranial is often marginal zone B-cell, while spinal is commonly diffuse large B-cell lymphoma.
• Primary dural lymphoma is under-represented in literature, possessing unique clinical and biological features.

Observation:

• A male patient presented with subacute progressive radiculopathy.
• A compressive infiltrative lumbosacral spinal lesion was identified.
• The lesion was diagnosed as primary dural diffuse large B-cell lymphoma.

Findings:

• Primary dural lymphoma demonstrates unique radiological and biological characteristics.
• Histological subtype varies by location: marginal zone B-cell lymphoma in the cranium, DLBCL in the spine.
• Optimal treatment algorithms for primary dural lymphoma are not well-defined.

Implications:

• Early surgical cytoreductive therapy may offer benefits.
• Low-dose radiotherapy could be an effective adjuvant treatment.
• Further research is needed to establish optimal therapeutic strategies for primary dural lymphoma.