Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Tissue Transplantation01:24

Tissue Transplantation

442
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
442
Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

30
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
30
Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

371
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
371

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Tolerance meets regenerative medicine: A new route to donor-specific allograft acceptance?

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2026
Same authorSame journal

People in Transplantation: Professor Nadey Hakim, MD, PhD, FRCS, FRCSGlas (Hon), FACS, President-Elect of The Transplantation Society.

Transplantation·2026
Same author

Anita Chong, PhD, Professor of Surgery, University of Chicago.

Transplantation·2026
Same author

Protocol for a phase I single-centre dose escalation trial of autologous thymus derived regulatory T cells in paediatric heart transplant recipients to prevent cardiac allograft vasculopathy (ATT-Heart).

BMJ open·2026
Same author

Clinical development of tacrolimus-resistant regulatory T cells to enable simultaneous immunosuppression and immune regulation.

Molecular therapy. Advances·2026
Same author

Vortex-actuated pre-enrichment accelerates human regulatory T cell sorting and improves early fitness.

Molecular therapy. Advances·2026
Same journal

Hepatic Congestion-linked Intrahepatic Biliary Strictures After Living Donor Liver Transplantation.

Transplantation·2026
Same journal

Filtered or Fried? Rethinking Intraoperative Cell Salvage in Liver Transplantation.

Transplantation·2026
Same journal

Simultaneous Liver-kidney Versus Liver Transplantation Categorized by Pretransplant eGFR: Impact of the 2017 OPTN Policy.

Transplantation·2026
Same journal

Preformed Anti-DQ Alpha Donor-specific Antibodies and the Risk of Antibody-mediated Rejection After Kidney Transplantation.

Transplantation·2026
Same journal

IL-1 Receptor Blockade Modulates Inflammation During Sequential Perfusion in Ex Vivo Porcine Kidneys.

Transplantation·2026
See all related articles

Related Experiment Video

Updated: Aug 6, 2025

Spatial Profiling of Protein and RNA Expression in Tissue: An Approach to Fine-Tune Virtual Microdissection
09:19

Spatial Profiling of Protein and RNA Expression in Tissue: An Approach to Fine-Tune Virtual Microdissection

Published on: July 6, 2022

5.0K

Opportunities for High-plex Spatial Transcriptomics in Solid Organ Transplantation.

Amy R Cross1, Lisa Gartner, Joanna Hester

  • 1Translational Research and Immunology Group, Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom.

Transplantation
|March 22, 2023
PubMed
Summary
This summary is machine-generated.

High-plex spatial transcriptomics analyzes mRNA in tissues, offering new insights for transplantation science. This technology can advance understanding of rejection, tolerance, and injury in transplant patients.

More Related Videos

Application of Laser Microdissection to Uncover Regional Transcriptomics in Human Kidney Tissue
05:46

Application of Laser Microdissection to Uncover Regional Transcriptomics in Human Kidney Tissue

Published on: June 9, 2020

4.0K
Using a Chemical Biopsy for Graft Quality Assessment
05:00

Using a Chemical Biopsy for Graft Quality Assessment

Published on: June 17, 2020

5.3K

Related Experiment Videos

Last Updated: Aug 6, 2025

Spatial Profiling of Protein and RNA Expression in Tissue: An Approach to Fine-Tune Virtual Microdissection
09:19

Spatial Profiling of Protein and RNA Expression in Tissue: An Approach to Fine-Tune Virtual Microdissection

Published on: July 6, 2022

5.0K
Application of Laser Microdissection to Uncover Regional Transcriptomics in Human Kidney Tissue
05:46

Application of Laser Microdissection to Uncover Regional Transcriptomics in Human Kidney Tissue

Published on: June 9, 2020

4.0K
Using a Chemical Biopsy for Graft Quality Assessment
05:00

Using a Chemical Biopsy for Graft Quality Assessment

Published on: June 17, 2020

5.3K

Area of Science:

  • Biotechnology
  • Molecular Biology
  • Transplantation Science

Background:

  • High-plex spatial transcriptomics technology has rapidly advanced, enabling in situ mRNA quantification.
  • Current applications are concentrated in neuroscience and oncology, with untapped potential in transplantation.

Approach:

  • This review discusses available spatial transcriptomic technologies.
  • It explores their application in analyzing complex tissue microenvironments within transplantation.

Key Points:

  • Spatial transcriptomics preserves spatial relationships within tissues while profiling mRNA.
  • It allows simultaneous measurement of numerous targets, including the whole transcriptome.
  • Transplant patients present a unique cohort for studying diverse disease processes.

Conclusions:

  • Spatial transcriptomics offers significant potential for advancing transplantation sciences.
  • It can identify novel therapeutic targets and biomarkers for rejection, tolerance, infection, and injury.
  • This technology can revolutionize the diagnosis and monitoring of transplant patients.