DT-0111: a novel P2X3 receptor antagonist

Area of Science:

• Pharmacology
• Neuroscience
• Respiratory Medicine

Background:

• Extracellular adenosine 5'-triphosphate (ATP) signals through P2 receptors (P2R), including P2X receptors (P2XRs).
• P2XRs are cationic channels, with P2X3 and P2X2/3 receptors on vagal nerve terminals mediating cough and bronchoconstriction.
• P2X3R and P2X2/3R antagonists are under development for chronic cough treatment.

Purpose of the Study:

• To present the receptor affinity data of a novel P2X3R antagonist, DT-0111.
• To evaluate DT-0111 as a potential therapeutic agent for conditions involving P2X3R activation.

Main Methods:

• Characterization of DT-0111 as a water-soluble small molecule.
• Assessment of DT-0111's affinity for P2X3 receptors.

Main Results:

• DT-0111 demonstrates selective antagonism of P2X3 receptors.
• The study provides quantitative receptor affinity data for DT-0111.

Conclusions:

• DT-0111 is a selective P2X3R antagonist with potential therapeutic applications.
• This compound warrants further investigation for the treatment of chronic cough and related conditions.