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Updated: Aug 6, 2025

In vitro Assessment of Myocardial Protection following Hypothermia-Preconditioning in a Human Cardiac Myocytes Model
Published on: October 27, 2020
Hypothermia is an independent risk factor for prolonged ICU stay in coronary artery bypass surgery: an observational
Yi-Chia Wang1, Hsing-Hao Huang1, Pei-Ching Lin1
1Department of Anesthesiology, National Taiwan University College of Medicine and National University Hospital, National Taiwan University Hospital, 7 Chung-Shan South Road, Taipei, Taiwan, 10002.
Insights
Hypothermia after cardiac surgery (CABG) did not increase mortality or infection but prolonged intensive care unit (ICU) stays. Maintaining normal body temperature is crucial for better patient recovery after CABG surgery.
Area of Science:
- Cardiology
- Anesthesiology
- Critical Care Medicine
Background:
- Maintaining normothermia is vital during the perioperative period.
- Warming after hypothermia can increase oxygen demand, potentially causing myocardial ischemia.
- The role of hypothermia as an independent risk factor for morbidity and mortality in CABG patients requires investigation.
Purpose of the Study:
- To determine if hypothermia is an independent risk factor for increased morbidity and mortality in patients undergoing Coronary Artery Bypass Grafting (CABG).
Main Methods:
- Retrospective observational study of 206 patients undergoing CABG from January 2018 to June 2019.
- Outcomes analyzed included mortality, surgical site infection, ventilator-dependent time, ICU stay, and hospitalization duration.
- Statistical analysis adjusted for factors including sex, age, cardiopulmonary bypass duration, left ventricular ejection fraction, and EuroSCORE II.
Main Results:
- No 30-day mortality was observed.
- Hypothermia was not linked to increased surgical site infection or longer intubation times.
- Hypothermia upon ICU admission, along with a higher EuroSCORE II, independently predicted prolonged ICU stay (OR 3.8 and 1.2, respectively).
Conclusions:
- Hypothermia upon ICU admission is an independent risk factor for prolonged ICU stay in elective CABG patients.
- While not linked to mortality or infection, hypothermia impacts recovery time.
- Optimizing perioperative temperature management is essential for improving patient outcomes after CABG.
Abstract:
Maintenance of normothermia is a critical perioperative issue. The warming process after hypothermia tends to increase oxygen demand, which may lead to myocardial ischemia. This study explored whether hypothermia was an independent risk factor for increased morbidity and mortality in patients receiving CABG. We conducted a retrospective observational study of CABG surgeries performed from January 2018 to June 2019. The outcomes of interest were mortality, surgical site infection rate, ventilator dependent time, intensive care unit (ICU) stay, and hospitalization duration. Data from 206 patients were analysed. Hypothermic patients were taller (p = 0.012), had lower left ventricular ejection fraction (p = 0.016), and had off-pump CABG more frequently (p = 0.04). Our analysis noted no incidence of mortality within 30 days. Hypothermia was not associated with higher surgical site infection rate or longer intubation time. After adjusting for sex, age, cardiopulmonary bypass duration, left ventricular ejection fraction, and EuroSCORE II, higher EuroSCORE II (p < 0.001; odds ratio 1.2) and hypothermia upon ICU admission (p = 0.04; odds ratio 3.8) were independent risk factors for prolonged ICU stay. In addition to EuroSCORE II, hypothermia upon ICU admission was an independent risk factor for prolonged ICU stay in patients receiving elective CABG.
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