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Related Concept Videos

The Respiratory System01:16

The Respiratory System

82.8K
The respiratory system is comprised of the organs that enable breathing. Air enters the nostrils and mouth, followed by the pharynx (throat) and larynx (voice box), which lead to the trachea (windpipe). In the thoracic cavity, the trachea splits into two bronchi that allow air to enter the lungs. The bronchi split into progressively smaller bronchioles and terminate in small groups of tiny sacs in the lungs called alveoli, where gas exchange occurs.
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Common Respiratory Disorders01:31

Common Respiratory Disorders

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Respiratory disorders, a prevalent health concern globally, are generally divided into two primary categories: upper and lower respiratory tract disorders. The categorization is based on the area of the respiratory system they affect.
Upper respiratory disorders impact the airways above the vocal cords, encompassing areas like the nose, sinuses, and throat. Various conditions fall under this category, including the common cold and allergic rhinitis. These disorders can stem from several causes,...
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Respiratory Volumes and Capacities01:22

Respiratory Volumes and Capacities

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The respiratory system is responsible for the intake of oxygen and the expulsion of carbon dioxide from the body. Respiratory volumes describe the volume of air in the lungs at different phases of the respiratory cycle. Tidal volume is the air breathed in and out during normal, quiet breathing. Inspiratory reserve volume is the air that can be forcefully inspired beyond the tidal volume. In contrast, expiratory reserve volume refers to the air that can be expelled from the lungs after a normal...
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Respiratory Assessment: Purpose and Indications01:19

Respiratory Assessment: Purpose and Indications

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Respiratory assessment is a cornerstone of nursing assessments, crucial for the early detection of patient deterioration. This evaluation transcends routine procedures, representing a critical skill nurses must master to ensure optimal patient care.
Objectives and Importance:
The primary goal of respiratory assessment is to evaluate patients at early risk of clinical deterioration. Since respiratory distress often precedes other signs of declining health, breathing patterns and sounds become a...
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Respiratory Volumes and Capacities I01:26

Respiratory Volumes and Capacities I

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Assessing the respiratory rate and rhythm for a complete minute is crucial for evaluating the breathing pattern. Even a minor increase in the patient's average respiratory rate, by as little as three to five breaths per minute, is an early and vital indicator of respiratory distress. Patients with a respiratory rate exceeding twenty-four breaths per minute require close monitoring to determine the physiological alterations. This careful observation is essential for prompt recognition and...
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Related Experiment Video

Updated: Aug 6, 2025

Purifying the Impure: Sequencing Metagenomes and Metatranscriptomes from Complex Animal-associated Samples
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Realising respiratory microbiomic meta-analyses: time for a standardised framework.

David Broderick1,2, Robyn Marsh3, David Waite1

  • 1School of Biological Sciences, University of Auckland, Auckland, New Zealand.

Microbiome
|March 22, 2023
PubMed
Summary

Meta-analyses are crucial for understanding variations in paediatric respiratory microbiota studies. This research highlights challenges and opportunities in this evolving field, emphasizing the need for data sharing and standardized practices.

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Area of Science:

  • Microbiome research
  • Paediatric respiratory health
  • Meta-analysis methodologies

Background:

  • Meta-analyses effectively identify technical variations in microbiome studies across diseases like gut and sinus.
  • Limited data exists for paediatric respiratory tract microbiomics, where sample acquisition is challenging.
  • Existing challenges include data accessibility, heterogeneity, and ethical considerations in paediatric respiratory microbiome research.

Discussion:

  • Paediatric respiratory microbiomics faces unique barriers, including evolving best practices and clinical heterogeneity.
  • Large-scale individual participant data meta-analyses are vital for advancing the field.
  • Ethical challenges can complicate data sharing in paediatric research.

Key Insights:

  • A large-scale meta-analysis (n=2624 children, 20 studies) was conducted on paediatric respiratory microbiota.
  • The study highlights significant barriers in paediatric respiratory microbiomics research.
  • Meta-analysis provides a powerful approach to leverage existing data and generate hypotheses.

Outlook:

  • Addressing data accessibility and heterogeneity is crucial for future paediatric respiratory microbiome studies.
  • Establishing standardized microbiome-related practices will enhance research reproducibility.
  • Fostering dialogue on ethical data sharing is essential for collaborative advancement.