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Disulfide Bond-Based SN38 Prodrug Nanoassemblies with High Drug Loading and Reduction-Triggered Drug Release for
Zhi-Xin Zhong1, Xu-Zhao Li1, Jin-Tao Liu1
1School of Pharmacy, Tianjin Medical University, Tianjin, 300070, People's Republic of China.
International Journal of Nanomedicine
|March 22, 2023
Summary
Researchers developed novel nanoassemblies (SNSS NAs) for targeted chemotherapy delivery. These SNSS NAs showed enhanced anti-tumor effects and improved safety in pancreatic cancer models, offering a promising new cancer treatment strategy.
Area of Science:
- Oncology
- Nanomedicine
- Drug Delivery
Background:
- Chemotherapy is a cornerstone of cancer treatment.
- Small molecular prodrug-based nanoassemblies (SMPDNAs) offer advantages like high drug loading, stability, and biocompatibility.
Purpose of the Study:
- To design and synthesize novel nanoassemblies (SNSS NAs) using a disulfide bond-inserted SN38 prodrug.
- To evaluate the in vitro and in vivo anti-tumor efficacy and biosafety of SNSS NAs in a pancreatic cancer model.
Main Methods:
- Rational design and preparation of SNSS NAs.
- Characterization of SNSS NAs.
- In vitro and in vivo evaluation of anti-tumor effects and biocompatibility.
Main Results:
- SNSS NAs demonstrated glutathione (GSH)-induced SN38 release and cytotoxicity in vitro.
- SNSS NAs exhibited passive tumor targeting and superior anti-tumor effects compared to irinotecan (CPT-11).
- Double dosage treatment showed satisfactory biocompatibility.
Conclusions:
- SNSS NAs provide a novel SN38-based nano-delivery system.
- The developed nanoassemblies show improved anti-tumor efficacy and biosafety for cancer treatment.
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