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Tissue Transplantation

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Updated: Aug 6, 2025

Optical Clearing of the Mouse Central Nervous System Using Passive CLARITY

Optical Clearing of the Mouse Central Nervous System Using Passive CLARITY

Published on: June 30, 2016

T-CLEARE: A Pilot Community-Driven Tissue-Clearing Protocol Repository.

Kurt Weiss¹, Jan Huisken¹, Vesselina Bakalov²

¹Morgridge Institute for Research, 330 N Orchard Street, Madison, WI, 53715, USA.

Biorxiv : the Preprint Server for Biology

|March 22, 2023

Summary

This summary is machine-generated.

Choosing a tissue-clearing protocol is difficult. T-CLEARE is a new, free repository that collects detailed protocol information and community feedback to help researchers find optimal tissue clearing methods.

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Last Updated: Aug 6, 2025

Optical Clearing of the Mouse Central Nervous System Using Passive CLARITY

Optical Clearing of the Mouse Central Nervous System Using Passive CLARITY

Published on: June 30, 2016

Imaging Cleared Intact Biological Systems at a Cellular Level by 3DISCO

Imaging Cleared Intact Biological Systems at a Cellular Level by 3DISCO

Published on: July 7, 2014

Novel Passive Clearing Methods for the Rapid Production of Optical Transparency in Whole CNS Tissue

Novel Passive Clearing Methods for the Rapid Production of Optical Transparency in Whole CNS Tissue

Published on: May 8, 2018

Area of Science:

Biological imaging
Histology
Biotechnology

Background:

Tissue clearing is a technique used to render biological tissues transparent for deep imaging.
Over 100 years old, tissue clearing remains a rapidly developing field with numerous protocols available.
Existing protocols often lack sufficient detail for replication and require extensive optimization for new applications.

Approach:

Developed T-CLEARE, a freely accessible online repository for tissue-clearing protocols.
Incorporated community feedback from surveys, capturing practical modifications and negative results.
Focused on details often missing in primary literature, such as specific use-case adaptations.

Key Points:

T-CLEARE addresses the challenge of selecting and implementing tissue-clearing protocols.
The repository includes community-sourced data on protocol performance, modifications, and limitations.
Aims to facilitate the identification of best-in-class tissue clearing methods for diverse applications.

Conclusions:

T-CLEARE provides a valuable resource for researchers in the field of tissue clearing.
Enhances reproducibility and efficiency by sharing detailed protocol information and user experiences.
Fosters a collaborative environment for advancing tissue clearing techniques.