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Related Concept Videos

Brain Imaging01:14

Brain Imaging

272
Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
272

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Related Experiment Video

Updated: Aug 6, 2025

Deep Brain Stimulation with Simultaneous fMRI in Rodents
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Mapping Dysfunctional Circuits in the Frontal Cortex Using Deep Brain Stimulation.

Barbara Hollunder1,2,3, Jill L Ostrem4, Ilkem Aysu Sahin1,2

  • 1Department of Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany.

Medrxiv : the Preprint Server for Health Sciences
|March 22, 2023
PubMed
Summary
This summary is machine-generated.

Deep brain stimulation mapping reveals distinct frontal cortex circuits implicated in dystonia, Tourette

Keywords:
ConnectomeDeep Brain Stimulation (DBS)DystoniaObsessive-Compulsive Disorder (OCD)Parkinson’s disease (PD)Structural ConnectivitySubthalamic Nucleus (STN)Tourette’s syndrome (TS)

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Area of Science:

  • Neuroscience
  • Neurology
  • Brain Mapping

Background:

  • Frontal circuits are crucial for motor, cognitive, and affective functions.
  • Dysfunction in these circuits is linked to various brain disorders, but specific domain involvement is unclear.

Approach:

  • Analyzed data from 534 deep brain stimulation (DBS) electrodes across four brain disorders.
  • Investigated how modulated connections correlate with optimal therapeutic response.
  • Mapped dysfunctional frontal circuits topographically based on DBS modulation patterns.

Key Points:

  • Segregated frontal cortex into distinct circuits based on their dysfunction in specific disorders.
  • Identified specific frontal circuit involvements: sensorimotor (dystonia), primary motor cortex (Tourette's syndrome), supplementary motor area (Parkinson's disease), and ventromedial prefrontal/anterior cingulate (obsessive-compulsive disorder).
  • Demonstrated a rostrocaudal topographical arrangement of these dysfunctional circuits.

Conclusions:

  • Deep brain stimulation combined with connectomics offers a powerful method to link brain structure to functional impairments.
  • Provides a refined understanding of frontal circuit topography and its role in neurological and psychiatric disorders.