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Retroperitoneal sarcomas: Outcomes of repeated resections
Hyeonuk Hwang1, Yoon-Hye Kwon1, Han-Ki Lim1
1Department of Surgery, Seoul National University College of Medicine, Seoul, Korea.
Korean Journal of Clinical Oncology
|March 22, 2023
Summary
Low tumor grade is a key factor for better outcomes in retroperitoneal sarcomas (RPS). Repeated surgeries for RPS recurrence do not worsen prognosis, supporting aggressive surgical approaches.
Area of Science:
- Surgical Oncology
- Medical Oncology
- Cancer Research
Background:
- Retroperitoneal sarcomas (RPS) are rare mesenchymal tumors.
- Understanding prognostic factors is crucial for improving patient survival.
Purpose of the Study:
- To review treatment experiences for RPS.
- To identify prognostic factors for overall survival (OS) after primary resection and reoperations for recurrences.
Main Methods:
- Retrospective review of 48 patients undergoing RPS resection (June 2002-December 2016).
- Univariate and multivariable Cox proportional hazards modeling used to assess prognostic factors for OS.
Main Results:
- Low tumor grade (Fédération Nationale des Centres de Lutte Contre le Cancer grade) was a significant favorable prognostic factor for OS in the primary resection group.
- Chemotherapy after primary resection was associated with poor prognosis (P=0.009).
- Five-year OS rates: 58.1% after primary resection, 64.3% after second resection for recurrence.
- Repeated resections for RPS recurrence were not associated with worse outcomes, with a 5-year OS of 75.0% in patients undergoing >3 resections.
Conclusions:
- Low tumor grade is the only independent favorable prognostic factor for OS in RPS.
- Despite a generally poor prognosis, aggressive surgical strategies for recurrent RPS are warranted.
- Repeated resections for RPS recurrence are not associated with poor prognosis.
