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Perianal extragastrointestinal stromal tumor
Ayoung Kang1, Sung Hwan Cho1, Byung-Soo Park1
1Department of General Surgery, Pusan National University Yangsan Hospital, Yangsan, Korea.
Korean Journal of Clinical Oncology
|March 22, 2023
Summary
Extragastrointestinal stromal tumors (EGISTs) are rare, particularly in the perianal region. This case highlights EGIST as a crucial differential diagnosis for perianal masses.
Area of Science:
- Gastroenterology
- Surgical Oncology
- Pathology
Background:
- Extragastrointestinal stromal tumors (EGISTs) originate outside the gastrointestinal tract, commonly in the omentum, mesentery, or retroperitoneum.
- Perianal EGISTs represent an exceedingly rare clinical presentation.
Observation:
- A 70-year-old male presented with a two-year history of anal discomfort.
- Pelvic MRI revealed a homogenous, well-defined soft tissue mass.
- Surgical excision and subsequent pathological examination confirmed the mass as an EGIST.
Findings:
- The perianal EGIST measured 4.3×3.2 cm with a low mitotic count (1/50 HPF).
- Immunohistochemistry showed positivity for KIT and CD34, with negativity for S-100 and alpha-smooth muscle actin.
- No other gastrointestinal tract abnormalities were identified.
Implications:
- EGISTs must be considered in the differential diagnosis of perianal masses.
- This case underscores the importance of comprehensive histopathological evaluation for rare perianal tumors.
- Awareness of EGISTs in this location can improve diagnostic accuracy and patient management.
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