[Influencing factors of recurrence of systemic lupus erythematosus: An update]

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease involving multiple tissues and organs. Frequent flare has been regarded as one of the main problems in the diagnosis and treatment of SLE, while the causes for frequent flare has remained to be unclear. We summarized the survival status and the situation of recurrence of SLE patients. The research progress regarding the recurrence and its mechanism will be reviewed from the aspects of genetic factors, environmental factors (i.e. infection, ultraviolet, vitamin D, chemical pollutants), drug and patient compliance, systemic damage and disease status, sex hormones and pregnancy, and social psychology. The implication is to explore effective clinical intervention to alleviate the SLE disease and improve the living quality of the patients.