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Type 1 diabetes and microscopic colitis: A nationwide matched case-control study in Sweden
Xiaoying Kang1,2, Shengxin Liu1, Bjorn Roelstraete1
1Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Alimentary Pharmacology & Therapeutics
|March 22, 2023
Summary
Type 1 diabetes (T1D) is nearly 80% more common in microscopic colitis (MC) patients. This association appears real, not due to shared genetics, but may be linked to MC-related medications.
Area of Science:
- Gastroenterology
- Endocrinology
- Immunology
Background:
- Microscopic colitis (MC) is an autoimmune-related colonic inflammatory condition.
- Type 1 diabetes (T1D) is an autoimmune disease targeting pancreatic beta-cells.
Purpose of the Study:
- To investigate the association between Type 1 diabetes (T1D) and microscopic colitis (MC).
Main Methods:
- A matched case-control study utilized the nationwide ESPRESSO cohort.
- Biopsy-confirmed MC cases were compared to biopsy-free controls matched for T1D diagnosis.
- Conditional logistic models estimated the T1D-MC association, with sibling and medication adjustments.
Main Results:
- T1D was 79% more prevalent in MC patients (OR 1.79).
- The association was stronger for collagenous colitis than lymphocytic colitis.
- The link remained significant in sibling comparisons, but attenuated in females after medication adjustment.
Conclusions:
- A significant association exists between T1D and MC.
- The association is unlikely to be solely due to shared genetics.
- Medications associated with MC may influence the observed T1D association.
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