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Visible light-induced direct alkylation of the purine C8-H bond with ethers
Changtong Lu1, Gary Histand2, Dongen Lin1
1Key Laboratory of Functional Molecular Engineering of Guangdong Province, School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510641, China. denlin@scut.edu.cn.
Abstract:
The one-step visible light-induced direct alkylation of the C8-H bond for purine derivatives by ethers was developed using Eosin Y as the photocatalyst and t-BuOOH as the oxidant at room temperature. This method describes the coupling of the α-C of the ether to the C8 of purine. Of particular interest is that substrates include purines with various functional groups and even unprotected 9H-purines. The protocol provides an effective method for the synthesis of 8-alkylpurine derivatives with high atom economy and high regioselectivity.
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