Related Experiment Video
Updated: Aug 6, 2025

Detection and Genogrouping of Noroviruses from Children's Stools By Taqman One-step RT-PCR
Published on: July 22, 2012
Genome characterisation of norovirus GII.P17-GII.17 detected during a large gastroenteritis outbreak in Romania in
Sorin Dinu1, Mihaela Oprea2, Ramona-Ionela Iordache2
1Molecular Epidemiology for Communicable Diseases Laboratory, Cantacuzino National Military Medical Institute for Research and Development, 103 Splaiul Independenței, Bucharest, 050096, Romania. sorindinu30@gmail.com.
Abstract:
Norovirus (NoV) is one of the leading causes of acute gastroenteritis worldwide. Genotype GII.P17-G.II.17 emerged in Asia between 2013 and 2015 and transiently replaced the GII.4 Sydney 2012 variant circulating at that time. We present the genome characterisation of a GII.P17-GII.17 strain causing a large outbreak in Romania in 2021. Our study shows that the 2021 strain belongs to a novel cluster of genotype GII.17, different from the two previously recognised P.17 clusters. Distinctive substitutions in predicted conformational epitopes of VP1 were identified for this new cluster. Also, our phylogenetic analysis showed the existence of another P.17 cluster grouping strains from France and Canada.
Related Concept Videos
Viruses with RNA Genomes
Viral Mutations
Genomics
Mutations in Microorganisms
Viruses of Archaea
Single Nucleotide Polymorphisms-SNPs

