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Updated: Aug 6, 2025

Assessment of Resistance to Tyrosine Kinase Inhibitors by an Interrogation of Signal Transduction Pathways by Antibody Arrays
07:42

Assessment of Resistance to Tyrosine Kinase Inhibitors by an Interrogation of Signal Transduction Pathways by Antibody Arrays

Published on: September 19, 2018

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Receptor tyrosine kinase inhibitors in cancer

Nasim Ebrahimi1, Elmira Fardi2, Hajarossadat Ghaderi3

  • 1Genetics Division, Department of Cell and Molecular Biology and Microbiology, Faculty of Science and Technology, University of Isfahan, Isfahan, Iran.

Cellular and Molecular Life Sciences : CMLS
|March 22, 2023
PubMed

Insights

Targeted therapy uses drugs to inhibit specific proteins like receptor tyrosine kinases (RTKs) in cancer cells, slowing tumor growth. Combination therapies show promise for overcoming drug resistance in cancer treatment.

Area of Science:

  • Oncology
  • Molecular Biology
  • Pharmacology

Background:

  • Targeted therapy represents a novel approach in cancer treatment.
  • Receptor tyrosine kinases (RTKs) are key proteins involved in cancer cell growth and proliferation.
  • RTK inhibitors (RTKIs) have been developed and some are in clinical use.

Purpose of the Study:

  • To discuss the structures, activation mechanisms, and functions of RTKs.
  • To explore the potential of combination drug therapy involving RTKIs for cancer treatment, particularly for drug-resistant cancers.

Main Methods:

  • Review of RTK structures, activation mechanisms, and functions.
  • Discussion of combination drug therapy strategies, including RTKIs with chemotherapy or immunotherapy agents.

Main Results:

  • Inhibiting RTKs can impede cancer progression.
  • Combination therapies may offer enhanced efficacy, especially in drug-resistant cases.

Conclusions:

  • Understanding RTKs is crucial for developing effective targeted therapies.
  • Combination drug strategies hold significant potential for improving outcomes in cancer patients, especially those with resistance to conventional treatments.
Keywords:
Cancer therapyDrug resistanceImmune therapyRTK inhibitorsTargeted therapy

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