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Related Concept Videos

Acute Coronary Syndrome I: Introduction01:30

Acute Coronary Syndrome I: Introduction

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Acute Coronary Syndrome (ACS) encompasses a spectrum of heart conditions caused by sudden obstruction of coronary arteries, typically resulting from the rupture of an atherosclerotic plaque and subsequent thrombus (blood clot) formation. This obstruction can lead to partial or complete blockage of blood flow, causing varying degrees of myocardial ischemia or infarction.ACS includes the following clinical entities:Unstable Angina (UA)Non-ST-Elevation Myocardial Infarction (NSTEMI)ST-Elevation...
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Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations01:19

Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations

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The pathophysiology of Acute Coronary Syndrome [ACD] involves several key processes:The main underlying cause of ACD is atherosclerosis, a chronic inflammatory disease characterized by the buildup of lipid-laden plaques within the coronary arteries.As the atherosclerotic plaque grows in the coronary artery, it may become unstable due to the formation of a lipid-rich core and a thin fibrous cap. Inflammatory cells within the plaque, such as macrophages, secrete enzymes that degrade the...
30
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

16
Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
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Myocarditis III: Medical Management01:14

Myocarditis III: Medical Management

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Myocarditis: Comprehensive Medical ManagementMyocarditis, the heart muscle inflammation, requires a comprehensive medical management strategy that addresses the underlying cause, provides supportive care, manages symptoms, and reduces cardiac workload.Infections and Autoimmune CausesAdminister appropriate antimicrobial therapy when an infectious agent causes myocarditis. For instance, penicillin treats infections caused by Group A Streptococcus. In cases where autoimmune processes are...
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Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

214
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
214
Ischemic Heart Disease: Overview01:17

Ischemic Heart Disease: Overview

1.4K
Ischemic heart disease occurs when the heart's blood supply dwindles, causing an ominous lack of oxygen and nutrients. This deficiency, stemming from reduced or obstructed blood flow, spells danger, leading to heart muscle damage and dysfunction.
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and...
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Updated: Aug 6, 2025

A Research Method For Detecting Transient Myocardial Ischemia In Patients With Suspected Acute Coronary Syndrome Using Continuous ST-segment Analysis
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A Research Method For Detecting Transient Myocardial Ischemia In Patients With Suspected Acute Coronary Syndrome Using Continuous ST-segment Analysis

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Risk of cancer after ST-segment-elevation myocardial infarction.

Maarten J G Leening1,2,3, Nathalie I Bouwer4,5, M Arfan Ikram6,7

  • 1Department of Cardiology, Erasmus MC - University Medical Center Rotterdam, PO Box 2040, 3000 CA, Rotterdam, the Netherlands. m.leening@erasmusmc.nl.

European Journal of Epidemiology
|March 22, 2023
PubMed
Summary

Myocardial infarction (MI) patients do not have a higher overall cancer risk. However, cancer incidence is elevated in the first three months post-MI, suggesting a potential early paraneoplastic link.

Keywords:
CancerEpidemiologyParaneoplasticPopulation-basedPrognosisST-segment-elevation myocardial infarction (STEMI)

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Postconditioning with Lactate-enriched Blood for Cardioprotection in ST-segment Elevation Myocardial Infarction
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Postconditioning with Lactate-enriched Blood for Cardioprotection in ST-segment Elevation Myocardial Infarction
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Area of Science:

  • Cardiology
  • Oncology
  • Epidemiology

Background:

  • Administrative data suggest increased cancer incidence after myocardial infarction (MI).
  • The link between MI and cancer is unclear, potentially due to pre-symptomatic cancer detection or shared risk factors.

Purpose of the Study:

  • To compare cancer incidence in ST-segment-elevation myocardial infarction (STEMI) survivors with the general population.
  • To investigate the temporal relationship and potential biological links between STEMI and subsequent cancer diagnoses.

Main Methods:

  • Compared 1809 STEMI patients with 10,052 general population individuals (Rotterdam Study).
  • Linked pathology-confirmed cancer diagnoses with the Netherlands Cancer Registry.
  • Used Cox models to calculate adjusted hazard ratios (HRs) over 5-year follow-up.

Main Results:

  • No significant difference in overall cancer incidence between STEMI patients and the general population (HR 0.96).
  • Markedly higher cancer incidence in STEMI patients within the first 3 months post-MI (HR 2.45), which decreased over time (P-trend 0.004).
  • In the first year post-STEMI, elevated C-reactive protein, platelet count, and low hemoglobin were associated with cancer incidence.

Conclusions:

  • The overall cancer risk is not elevated after STEMI.
  • The early post-STEMI cancer surge suggests STEMI may be a paraneoplastic manifestation of undiagnosed cancer.
  • Pro-inflammatory status and anemia characterize STEMI as a potential paraneoplastic syndrome.