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Increased gestational palmitic acid predisposes offspring to congenital heart disease

Yang Lv1, Ri-Feng Gao1, Chen-Xi Yang1

  • 1Department of Cardiology, Shanghai Fifth People's Hospital, Fudan University, Shanghai, China.

Cell Reports. Medicine
|March 22, 2023
PubMed

Insights

Gestational exposure to palmitic acid (PA) increases congenital heart disease (CHD) risk in offspring. This occurs by disrupting the MARS/K-Hcy/GATA4 signaling pathway, offering targets for prevention and treatment.

Area of Science:

  • Cardiovascular Biology
  • Developmental Biology
  • Metabolomics

Background:

  • Congenital heart disease (CHD) poses a significant global health challenge.
  • Understanding the etiology of CHD is crucial for effective prevention and personalized therapies.

Purpose of the Study:

  • To investigate the role of gestational serum palmitic acid (PA) in the development of congenital heart disease (CHD).
  • To elucidate the molecular mechanisms by which PA influences CHD pathogenesis.

Main Methods:

  • Analysis of gestational serum palmitic acid levels.
  • Investigation of the MARS/K-Hcy/GATA4 signaling pathway in affected offspring.
  • Correlation studies between PA levels and CHD incidence.

Main Results:

  • Elevated gestational serum palmitic acid (PA) levels were found to be associated with an increased risk of congenital heart disease (CHD) in offspring.
  • PA was demonstrated to perturb the MARS/K-Hcy/GATA4 signaling pathway, a critical pathway in heart development.

Conclusions:

  • Gestational palmitic acid exposure is a potential risk factor for congenital heart disease.
  • The MARS/K-Hcy/GATA4 pathway is a key mediator of PA-induced cardiotoxicity, presenting a potential therapeutic target for CHD.

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