Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

601
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
601
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

4.1K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.1K
Cancer Vaccines01:30

Cancer Vaccines

460
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
460
Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

5.0K
Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
5.0K
iPS Cell Differentiation01:22

iPS Cell Differentiation

2.8K
The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
2.8K
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

5.0K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Precise Cancer Anti-acid Therapy Monitoring Using pH-Sensitive MnO<sub>2</sub>@BSA Nanoparticles by Magnetic Resonance Imaging.

ACS applied materials & interfaces·2021
Same author

Effects of histone H4 hyperacetylation on inhibiting MMP2 and MMP9 in human amniotic epithelial cells and in premature rupture of fetal membranes.

Experimental and therapeutic medicine·2021
Same author

Regulatory roles and mechanisms of alternative RNA splicing in adipogenesis and human metabolic health.

Cell & bioscience·2021
Same author

Diluted-CdS Quantum Dot-Assisted SnO<sub>2</sub> Electron Transport Layer with Excellent Conductivity and Suitable Band Alignment for High-Performance Planar Perovskite Solar Cells.

ACS applied materials & interfaces·2021
Same author

A microporous surface containing Si<sub>3</sub>N<sub>4</sub>/Ta microparticles of PEKK exhibits both antibacterial and osteogenic activity for inducing cellular response and improving osseointegration.

Bioactive materials·2021
Same author

Clinical importance of ADC in the prediction of <sup>125</sup>I in the treatment for gliomas.

Journal of Cancer·2021
Same journal

Psychological stress drives aging-like hematopoietic stem cell dysfunction through a brain-gut-bone marrow axis.

Cell stem cell·2026
Same journal

Human stem cell-based embryo model governance: Insights from Japan.

Cell stem cell·2026
Same journal

From reconstruction to intervention: Engineered organoids as living therapeutic depots.

Cell stem cell·2026
Same journal

Long-term lessons from MATCH01 macrophage therapy in cirrhosis.

Cell stem cell·2026
Same journal

Beyond apoptosis: LSC state dictates metabolic and anti-apoptotic vulnerabilities.

Cell stem cell·2026
Same journal

Outside the niche: Gut microbiota relay psychological stress to hematopoietic stem cell dysfunction.

Cell stem cell·2026
See all related articles

Related Experiment Video

Updated: Aug 6, 2025

Advances in Human Induced Pluripotent Stem Cell-Derived Chimeric Antigen Receptor-Expressing Natural Killer Cells
11:08

Advances in Human Induced Pluripotent Stem Cell-Derived Chimeric Antigen Receptor-Expressing Natural Killer Cells

Published on: February 14, 2025

907

Advancing cell-based cancer immunotherapy through stem cell engineering.

Yan-Ruide Li1, Zachary Spencer Dunn2, Yanqi Yu1

  • 1Department of Microbiology, Immunology & Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA.

Cell Stem Cell
|March 22, 2023
PubMed
Summary
This summary is machine-generated.

Engineered stem cells offer a promising alternative to current CAR-T cell therapies for blood cancers. These stem cell-based immunotherapies aim to overcome the limitations of existing treatments, including cost and efficacy against solid tumors.

Keywords:
CRISPR-Cas9T cellT cell receptorallogeneic off-the-shelf cell therapyallorejectioncancer immunotherapychimeric antigen receptorembryonic stem cellfeeder-free culturegamma delta T cellgene engineeringgraft-versus-host diseasehematopoietic stem cellimmune cellinduced pluripotent stem cellinvariant natural killer T celllentivectormucosal-associated invariant T cellnatural killer cellstem cell

More Related Videos

Generation of a Novel Dendritic-cell Vaccine Using Melanoma and Squamous Cancer Stem Cells
12:43

Generation of a Novel Dendritic-cell Vaccine Using Melanoma and Squamous Cancer Stem Cells

Published on: January 6, 2014

11.9K
Using Human Induced Pluripotent Stem Cells for the Generation of Tumor Antigen-specific T Cells
10:57

Using Human Induced Pluripotent Stem Cells for the Generation of Tumor Antigen-specific T Cells

Published on: October 24, 2019

10.5K

Related Experiment Videos

Last Updated: Aug 6, 2025

Advances in Human Induced Pluripotent Stem Cell-Derived Chimeric Antigen Receptor-Expressing Natural Killer Cells
11:08

Advances in Human Induced Pluripotent Stem Cell-Derived Chimeric Antigen Receptor-Expressing Natural Killer Cells

Published on: February 14, 2025

907
Generation of a Novel Dendritic-cell Vaccine Using Melanoma and Squamous Cancer Stem Cells
12:43

Generation of a Novel Dendritic-cell Vaccine Using Melanoma and Squamous Cancer Stem Cells

Published on: January 6, 2014

11.9K
Using Human Induced Pluripotent Stem Cells for the Generation of Tumor Antigen-specific T Cells
10:57

Using Human Induced Pluripotent Stem Cells for the Generation of Tumor Antigen-specific T Cells

Published on: October 24, 2019

10.5K

Area of Science:

  • Immunotherapy
  • Cellular Therapy
  • Hematological Malignancies

Background:

  • Chimeric antigen receptor T-cell (CAR-T) therapy has revolutionized hematological malignancy treatment.
  • Autologous CAR-T therapies face challenges such as high costs, manufacturing complexity, and limited effectiveness in solid tumors.

Purpose of the Study:

  • To review stem cell-based immunotherapy approaches as a potential solution to CAR-T therapy limitations.
  • To explore advancements in gene editing and culture techniques for engineered stem cells in therapy.

Main Methods:

  • Review of stem cell sources and gene engineering strategies.
  • Analysis of therapeutic platforms and manufacturing approaches.
  • Examination of current clinical trials and future directions.

Main Results:

  • Stem cell-based immunotherapies show potential to address challenges associated with CAR-T therapy.
  • Progress in gene editing and culture techniques facilitates engineered stem cell development.
  • Ongoing research focuses on overcoming manufacturing and efficacy hurdles.

Conclusions:

  • Engineered stem cells represent a significant advancement in cell-based immunotherapy.
  • Further research and clinical trials are necessary to fully realize the potential of stem cell-based therapies for various cancers.