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Updated: Aug 6, 2025
Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
Published on: January 18, 2018
IScore, a useful prognostic tool for patients with acute ischemic stroke treated with intravenous thrombolysis: a
Valéria Cristina Scavasine1, Rebeca Teixeira Costa1, Viviane de Hiroki Flumignan Zétola1
1Universidade Federal do Paraná, Hospital de Clínicas, Divisão de Neurologia, Curitiba PR, Brasil.
Insights
The Ischemic Stroke Predictive Risk Score (IScore) shows moderate sensitivity and high specificity for predicting poor outcomes in stroke patients receiving thrombolysis, aiding clinical decisions.
Area of Science:
- Neurology
- Clinical Medicine
- Public Health
Background:
- Stroke is a leading global cause of death and disability.
- Over 50% of stroke survivors experience long-term disability.
- Predictive scores can objectively assess stroke outcome risks.
Purpose of the Study:
- To validate the Ischemic Stroke Predictive Risk Score (IScore) in patients receiving intravenous thrombolysis.
- To compare IScore predictions with actual 30-day and 1-year death and disability outcomes.
Main Methods:
- Retrospective study of 239 patients from a Brazilian Stroke Unit.
- Application of the IScore using admission data.
- Receiver Operating Characteristic (ROC) curve analysis for sensitivity and specificity.
Main Results:
- The IScore demonstrated moderate sensitivity and high specificity.
- Validation was performed for 30-day and 1-year post-stroke outcomes.
Conclusions:
- The IScore is a viable objective prognostic tool for stroke patients undergoing thrombolysis.
- It can assist clinicians in therapeutic decision-making and end-of-life care planning.
Background:
Stroke is one of the major causes of disability and mortality worldwide. Up to 30% of individuals who experience stroke die within 30 days, and more than 50% of those who survive will have some degree of disability. There are some predetermining factors based on admission data that could be used to objectively assess the odds of poor outcomes, including the Ischemic Stroke Predictive Risk Score (IScore).
Objective:
To analyze and validate the IScore in patients undergoing intravenous thrombolysis for stroke and compare the results of this predictor with actual death and disability outcomes.
Methods:
In a retrospective study, data were collected from a database housed at the Stroke Unit of the Teaching Hospital of Universidade Federal do Paraná, Southern Brazil. The IScore was applied to admission data from 239 patients, and the results were compared with actual outcomes (death and disability) within 30 days and 1 year after the stroke event. Data analysis was performed using an analysis of the receiver operating characteristic (ROC) curve to determine the sensitivity and specificity of the IScore in the study population.
Results:
The IScore demonstrated moderate sensitivity and high specificity in patients with stroke who underwent thrombolysis when evaluated after 30 days and 1 year of the event.
Conclusions:
The IScore can be applied to in stroke patients undergoing thrombolysis; therefore, it may be used as an objective prognostic tool to guide clinical decision-making. Understanding the prognosis of patients in the acute phase can assist clinicians in making the best therapeutic decisions and enable better end-of-life care.
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