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Related Concept Videos

Regulation of Expression Occurs at Multiple Steps02:24

Regulation of Expression Occurs at Multiple Steps

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Gene expression can be regulated at almost every step from gene to protein. Transcription is the step that is most commonly regulated. This involves the binding of proteins to short regulatory sequences on the DNA. This association can either promote or inhibit the transcription of a gene associated with the respective sequence.
Transcription results in the generation of precursor (pre-mRNA) that consists of both exons and introns, which needs further processing before being translated to a...
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Regulation of Expression at Multiple Steps01:23

Regulation of Expression at Multiple Steps

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The gene expression in cells is regulated at different stages: (i) transcription, (ii) RNA processing, (iii) RNA localization, and (iv) translation. Transcriptional regulation is mediated by regulatory proteins such as transcription factors, activators, or repressors—these control gene expression by initiating or inhibiting the transcription of genes. Once a precursor or pre-mRNA is produced, it undergoes post-transcriptional modification, including 5' capping, splicing, and the...
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Transcriptional Regulation: Riboswitches01:23

Transcriptional Regulation: Riboswitches

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Riboswitches are RNA elements that regulate gene expression by altering their secondary structures in response to specific effector molecules. These elements, located in the leader regions of certain mRNAs, act as transcriptional regulators by toggling between alternative conformations to control downstream gene expression. Riboswitch-mediated regulation is a precise mechanism for modulating biosynthetic pathways, as exemplified by the riboflavin biosynthesis pathway in Bacillus...
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Signal Transduction: Overview01:26

Signal Transduction: Overview

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Cells respond to many types of information, often through receptor proteins positioned on the membrane. They respond to chemical signals, such as hormones, neurotransmitters, and other signaling molecules, initiating a series of molecular reactions to produce an appropriate response. This is called signal transduction. Cells also coordinate different responses elicited by the same signaling molecule via mediators, allowing molecular cross-talk.
Typically, signal transduction involves three...
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General Transcription Factors01:30

General Transcription Factors

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Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
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Structural Protein Function01:56

Structural Protein Function

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Related Experiment Video

Updated: Aug 6, 2025

The c-FOS Protein Immunohistological Detection: A Useful Tool As a Marker of Central Pathways Involved in Specific Physiological Responses In Vivo and Ex Vivo
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Fosl1: friend or foe?

Shruti Bhargava1, Joachim Jankowski2

  • 1Institute of Molecular Cardiovascular Research, Medical Faculty, RWTH Aachen University, Aachen, Germany.

Kidney International
|March 22, 2023
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Summary

Fos-like antigen 1 (Fosl1) protein impacts kidney injury and fibroblast growth factor. Researchers discovered Fosl1 preserves Klotho expression, revealing a new avenue for kidney protection.

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FSL Constructs: A Simple Method for Modifying Cell/Virion Surfaces with a Range of Biological Markers Without Affecting their Viability
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Area of Science:

  • Molecular Biology
  • Nephrology
  • Genetics

Background:

  • Fos-like antigen 1 (Fosl1) is a transcription factor involved in carcinogenesis, acute kidney injury, and fibroblast growth factor regulation.
  • Recent findings suggest a role for Fosl1 in kidney health.

Purpose of the Study:

  • To investigate the nephroprotective effects of Fos-like antigen 1 (Fosl1).
  • To explore the relationship between Fosl1 and Klotho expression in the context of kidney protection.

Main Methods:

  • Analysis of Fosl1's role in cellular pathways.
  • Examination of Klotho expression levels in relation to Fosl1 activity.

Main Results:

  • Fosl1 demonstrates a nephroprotective effect.
  • This protection is mediated through the preservation of Klotho expression.

Conclusions:

  • The link between Fosl1 and Klotho expression opens a novel field in nephroprotection.
  • Targeting Fosl1 may offer therapeutic strategies for kidney diseases.