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Related Concept Videos

Major Hormones and Their Functions01:27

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Related Experiment Video

Updated: Aug 6, 2025

Comparative Analysis of Human Growth Hormone in Serum Using SPRi, Nano-SPRi and ELISA Assays
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Growth Hormone and Aging.

Camille Hage1, Roberto Salvatori1

  • 1Division of Endocrinology, Diabetes, & Metabolism, Department of Medicine, Johns Hopkins University School of Medicine, 1830 east Monument street #333 Baltimore, MD 21287, USA.

Endocrinology and Metabolism Clinics of North America
|March 22, 2023
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Growth hormone (GH) decline is common in aging. Current evidence on GH treatment for older adults is controversial and lacks placebo-controlled studies, with limited indications for GH therapy in adults.

Keywords:
GH deficiencyGH resistanceGrowth hormoneHuman agingSomatopause

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Area of Science:

  • Gerontology
  • Endocrinology
  • Hormone Therapy

Background:

  • Growth hormone (GH) secretion naturally decreases with age, a process known as somatopause.
  • The role of GH decline in aging and the efficacy/safety of GH treatment in older adults remain subjects of debate.
  • Existing research on GH and longevity in humans yields conflicting results, unlike some animal studies suggesting a link between lower GH levels and increased lifespan.

Purpose of the Study:

  • To critically evaluate the controversial topic of growth hormone (GH) treatment in aging individuals without pituitary pathology.
  • To review the current evidence regarding the effects of GH decline and potential GH therapy on longevity in humans.
  • To clarify the established indications for GH treatment in adult populations.

Main Methods:

  • Review of existing literature, focusing on studies examining GH levels in aging.
  • Analysis of clinical trial data, particularly noting the scarcity of placebo-controlled studies on GH treatment in the elderly.
  • Examination of research on the association between GH deficiency (GHD) and lifespan in both animal and human models.

Main Results:

  • Most available information on GH treatment in older adults stems from non-placebo-controlled studies.
  • Animal studies often associate decreased GH with increased lifespan, but human data present contradictory findings on GHD's impact on longevity.
  • Current clinical guidelines restrict GH treatment to specific cases of GHD originating in childhood or due to pituitary issues.

Conclusions:

  • The use of GH therapy in aging individuals without diagnosed pituitary pathology is controversial and lacks robust scientific support.
  • Further well-designed, placebo-controlled studies are needed to ascertain the true effects of GH modulation on aging and longevity in humans.
  • Established indications for GH treatment in adults remain limited to specific GHD conditions.