Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Diabetes Mellitus: Overview and Type I Subtype01:22

Diabetes Mellitus: Overview and Type I Subtype

2.8K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
2.8K
Diabetes: Symptoms, Diagnosis, and Complications01:15

Diabetes: Symptoms, Diagnosis, and Complications

623
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
623
Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

2.6K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.6K
Carbohydrate Metabolism01:36

Carbohydrate Metabolism

11.3K
Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
11.3K
Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

1.1K
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
1.1K
Insulin: Dosing Regimen and Adverse Effects01:16

Insulin: Dosing Regimen and Adverse Effects

220
Insulin-replacement therapy usually includes both long-acting insulin (basal) and short-acting insulin (to cater to postprandial needs). In a diverse group of type 1 diabetes patients, the average daily insulin dose is typically 0.5-0.7 units/kg body weight. However, obese patients and pubertal adolescents may need more due to insulin resistance.
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
220

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Erratum. Diabetes Body Project: Acute Effects of an Eating Disorder Prevention Program for Young Women With Type 1 Diabetes. A Multinational Randomized Controlled Trial. Diabetes Care 2025;48:220-225.

Diabetes care·2026
Same author

Gordon C. Weir, 3 December 1940-27 March 2026.

Diabetologia·2026
Same author

Psychoeducation for adults with type 1 diabetes and problematic hypoglycemia: implementation analysis of a clinical trial (HARPdoc).

Frontiers in health services·2026
Same author

Can the Diabetes Eating Problem Survey-Revised (DEPS-R) reliably identify eating disorder diagnosis in women with type 1 diabetes?

Diabetic medicine : a journal of the British Diabetic Association·2026
Same author

Preparing to Meet the Needs of a Growing Older Adult Population with Type 1 Diabetes: A Narrative Review.

Journal of general internal medicine·2025
Same author

Continuous Glucose Monitoring in Older Adults With Diabetes and Alzheimer Disease and Related Dementias-Promise and Perspective.

JAMA network open·2025

Related Experiment Video

Updated: Aug 6, 2025

Osmotic Minipump Implantation for Increasing Glucose Concentration in Mouse Cerebrospinal Fluid
06:21

Osmotic Minipump Implantation for Increasing Glucose Concentration in Mouse Cerebrospinal Fluid

Published on: April 7, 2023

1.6K

Type 1 Diabetes and Aging.

Elena Toschi1

  • 1Joslin Diabetes Center; Beth Israel Deaconess Medical Center; Harvard Medical School, One Joslin Place, Boston, MA 02215, USA.

Endocrinology and Metabolism Clinics of North America
|March 22, 2023
PubMed
Summary
This summary is machine-generated.

Older adults with type 1 diabetes (T1D) face unique challenges, including a high risk of hypoglycemia. Personalized care and advanced technologies are crucial for managing T1D in this growing population.

Keywords:
Continuous glucose monitoring (CGM)Health statusOlder adultsSubcutaneous continuous insulin infusionTechnologyType 1 diabetes mellitus (T1D)

More Related Videos

Accelerated Type 1 Diabetes Induction in Mice by Adoptive Transfer of Diabetogenic CD4+ T Cells
06:27

Accelerated Type 1 Diabetes Induction in Mice by Adoptive Transfer of Diabetogenic CD4+ T Cells

Published on: May 6, 2013

16.8K
Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People
12:59

Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People

Published on: July 5, 2017

12.7K

Related Experiment Videos

Last Updated: Aug 6, 2025

Osmotic Minipump Implantation for Increasing Glucose Concentration in Mouse Cerebrospinal Fluid
06:21

Osmotic Minipump Implantation for Increasing Glucose Concentration in Mouse Cerebrospinal Fluid

Published on: April 7, 2023

1.6K
Accelerated Type 1 Diabetes Induction in Mice by Adoptive Transfer of Diabetogenic CD4+ T Cells
06:27

Accelerated Type 1 Diabetes Induction in Mice by Adoptive Transfer of Diabetogenic CD4+ T Cells

Published on: May 6, 2013

16.8K
Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People
12:59

Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People

Published on: July 5, 2017

12.7K

Area of Science:

  • Geriatric Medicine
  • Endocrinology
  • Diabetes Management

Background:

  • Increasing prevalence of type 1 diabetes (T1D) in older adults due to improved longevity and diabetes care.
  • This demographic presents heterogeneity owing to aging, comorbidities, and diabetes-related complications.
  • Significant risk of hypoglycemia unawareness and severe hypoglycemia is noted in older adults with T1D.

Purpose of the Study:

  • To highlight the challenges in managing type 1 diabetes in an aging population.
  • To emphasize the need for tailored glycemic targets and regular health assessments.
  • To explore the potential of modern diabetes technologies for this cohort.

Main Methods:

  • Review of current literature on T1D management in older adults.
  • Analysis of risks associated with aging and comorbidities in T1D patients.
  • Evaluation of emerging technologies like continuous glucose monitoring and insulin pumps.

Main Results:

  • Older adults with T1D are a complex group requiring individualized care strategies.
  • Proactive management is essential to prevent severe hypoglycemia and its consequences.
  • Advanced technologies show promise in improving glycemic control and safety.

Conclusions:

  • Periodic health status assessment and adjusted glycemic goals are imperative for older adults with T1D.
  • Continuous glucose monitoring, insulin pumps, and hybrid closed-loop systems offer significant benefits.
  • These tools can enhance glycemic control and reduce hypoglycemia risk in this population.