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When cleaning facilitates cluttering - genome editing in ciliates
Brandon Kwee Boon Seah1, Estienne Carl Swart1
1Max Planck Institute for Biology, 72076 Tübingen, Germany.
Trends in Genetics : TIG
|March 22, 2023
Abstract:
Many organisms remove DNA from their genomes during development. This has foremost been characterized as a means of defending genomes against mobile elements. However, genome editing actually hides such elements from purifying selection, with the survivors evolving approximately neutrally, 'cluttering' the germline genome, enabling it to enlarge over time.
Keywords:
epigeneticsgenome defensegenome editinggenome reorganizationgermline–soma differentiationtransposable elements
