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Two cases of systemic lupus erythematosus associated with hyperthyroidism.
S Sakata1, S Nakamura, K Nagai
1Third Department of Internal Medicine, Gifu University School of Medicine, Japan.
Japanese Journal of Medicine
|August 1, 1987
Summary
Systemic lupus erythematosus (SLE) with hyperthyroidism can be managed by adjusting treatments. In two cases, adjusting antithyroid and steroid medications improved both conditions.
Area of Science:
- Endocrinology
- Rheumatology
- Internal Medicine
Background:
- Systemic lupus erythematosus (SLE) is a chronic autoimmune disease.
- Hyperthyroidism is a condition involving overactive thyroid gland.
- Co-occurrence of SLE and hyperthyroidism presents complex management challenges.
Observation:
- Two female patients (21 and 26 years old) presented with coexisting SLE and hyperthyroidism.
- Case 1 showed SLE deterioration despite methimazole (MMI) and betamethasone treatment for hyperthyroidism.
- Case 2 experienced severe gastric hemorrhage while on prednisolone for SLE, complicated by hyperthyroidism.
Findings:
- Case 1 improved significantly after discontinuing MMI and continuing betamethasone alone for SLE and hyperthyroidism.
- Case 2 was successfully treated with intermittent prednisolone for SLE, alongside management of hyperthyroidism.
- Both patients demonstrated improvement in physical findings and laboratory markers for both SLE and hyperthyroidism with adjusted therapies.
Implications:
- Treatment strategies for hyperthyroidism may need careful consideration in SLE patients.
- Steroid-sparing or adjusted steroid regimens can be effective in managing SLE with comorbidities.
- Optimizing treatment for one condition can positively impact the other, improving overall patient outcomes.