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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
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Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
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Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
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Related Experiment Video

Updated: Aug 6, 2025

Establishment of a Human Multiple Myeloma Xenograft Model in the Chicken to Study Tumor Growth, Invasion and Angiogenesis
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Stem cell mobilization in multiple myeloma: challenges, strategies, and current developments.

Xiaolei Wei1, Yongqiang Wei2

  • 1Department of Hematology, Nanfang Hospital, Southern Medical University, No. 1838 Guangzhou Avenue North, Guangzhou, 510515, China.

Annals of Hematology
|March 23, 2023
PubMed
Summary

Mobilization strategies for peripheral blood stem cells (PBSCs) in multiple myeloma (MM) are crucial for autologous hematopoietic stem cell transplantation (auto-HCT). This review examines strategies, graft impact, and factors influencing mobilization success in MM patients.

Keywords:
Graft characteristicsMobilization regimenMultiple myelomaStem cell mobilization

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Area of Science:

  • Hematology
  • Oncology
  • Transplantation Medicine

Background:

  • Multiple myeloma (MM) is a hematological malignancy where autologous hematopoietic stem cell transplantation (auto-HCT) is a primary treatment.
  • Peripheral blood stem cells (PBSCs) are predominantly used for auto-HCT, making their mobilization and collection critical steps.

Purpose of the Study:

  • To review and summarize various PBSC mobilization strategies in MM patients.
  • To discuss the evolution of these strategies and their impact on graft content and clinical outcomes.
  • To explore factors predicting poor mobilization and potential regimens for affected patients.

Main Methods:

  • Comprehensive literature review of PBSC mobilization strategies in MM.
  • Analysis of existing evidence on the relationship between mobilization regimens, graft characteristics, and patient outcomes.
  • Discussion of factors influencing mobilization failure and predictive markers.

Main Results:

  • While novel agents have improved PBSC mobilization in MM, mobilization failure remains a concern.
  • The chosen mobilization regimen can significantly influence graft content.
  • Limited data exist on the impact of graft characteristics beyond hematopoietic engraftment on clinical outcomes.

Conclusions:

  • Understanding mobilization strategies and their impact on graft characteristics is vital for optimizing auto-HCT in MM.
  • Further research is needed to elucidate the effect of graft characteristics on broader clinical outcomes.
  • Identifying predictive factors for poor mobilization can guide the selection of appropriate strategies for individual MM patients.