Related Experiment Video
Updated: Aug 6, 2025
12:55
Generation of CAR T Cells for Adoptive Therapy in the Context of Glioblastoma Standard of Care
Published on: February 16, 2015
21.5K
Combining chemotherapy with CAR-T cell therapy in treating solid tumors
Arthur Xuan Wang1, Xiao Jing Ong1, Criselle D'Souza1,2
1Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.
Frontiers in Immunology
|March 23, 2023
Summary
Chemotherapy combined with Chimeric Antigen Receptor T (CAR-T) cell therapy shows promise for cancer treatment. This approach can enhance CAR-T cell effectiveness by depleting immunosuppressive cells and improving tumor microenvironments, though challenges remain.
Area of Science:
- Oncology
- Immunotherapy
Background:
- Chemotherapy is a standard cancer treatment, often preceding Chimeric Antigen Receptor T (CAR-T) cell therapy to aid engraftment.
- Commonly used agents like cyclophosphamide and fludarabine are employed for lymphodepletion.
Purpose of the Study:
- To review the combined use of chemotherapy and CAR-T cell therapy.
- To explore how chemotherapy influences the tumor microenvironment and CAR-T cell activity.
Main Methods:
- This is a review article, synthesizing existing research on combined chemotherapy and CAR-T cell therapy.
Main Results:
- Chemotherapy can deplete immunosuppressive cells, create a pro-inflammatory tumor microenvironment, and disrupt tumor stroma.
- These effects may enhance CAR-T cell recruitment and improve therapeutic outcomes.
Conclusions:
- The combination of chemotherapy and CAR-T cell therapy is a promising strategy for cancer treatment.
- Challenges exist, and optimal outcomes depend on chemotherapy dosage and treatment scheduling.
Keywords:
Chimeric Antigen Receptor T cell (CAR-T)chemotherapypersonalized combinationsolid tumortumor microenvironment (TME)More Related Videos
Related Concept Videos
01:27Tumor Immunotherapy
600
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
600
02:50Combination Therapies and Personalized Medicine
5.0K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.0K
02:57Targeted Cancer Therapies
7.7K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.7K
02:49Cancer Therapies
7.9K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.9K
02:56Treatment Resistant Cancers
3.4K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.4K