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The causal relationship between COVID-19 and increased intraocular pressure: A bidirectional two-sample Mendelian
Yi Lin1, Bingcai Jiang1, Yuanqing Cai2
1Department of Ophthalmology, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Frontiers in Public Health
|March 23, 2023
Summary
Hospitalization for COVID-19 may increase intraocular pressure (IOP). Monitoring IOP in hospitalized COVID-19 patients is recommended. This study explored the causal link between COVID-19 and IOP using Mendelian randomization.
Area of Science:
- Ophthalmology
- Infectious Diseases
- Genetics
Background:
- Coronavirus disease 2019 (COVID-19) presents significant global public health and economic challenges.
- The causal relationship between COVID-19 and intraocular pressure (IOP) was previously unclear.
Purpose of the Study:
- To investigate the potential causal associations between COVID-19 susceptibility, severity, and criticality and intraocular pressure (IOP).
- To utilize bidirectional Mendelian randomization (MR) analysis to explore these relationships.
Main Methods:
- Employed genetic data from the COVID-19 Host Genetics Initiative and GWAS summary data for IOP.
- Utilized the inverse variance weighted (IVW) method for primary analysis, supplemented by other methods.
- Conducted sensitivity analyses to ensure the reliability and stability of the findings.
Main Results:
- No significant causal effect of COVID-19 susceptibility on IOP was observed (P = 0.533).
- COVID-19 severity, specifically hospitalization, showed a nominal positive association with increased IOP (P = 0.049).
- No significant causal effect of COVID-19 criticality or IOP on COVID-19 was found.
Conclusions:
- Hospitalization due to COVID-19 may be associated with an increase in intraocular pressure.
- Increased attention and IOP monitoring are warranted for hospitalized COVID-19 patients.
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