PhysiPKPD: A pharmacokinetics and pharmacodynamics module for PhysiCell.

Area of Science:

• Computational Biology
• Mathematical Biology
• Pharmacology

Background:

• Pharmacokinetics and pharmacodynamics (PKPD) are crucial for understanding molecular therapies.
• Integrating PKPD into in silico models of biological tissues is essential for accurate simulations.
• A standardized and flexible framework for PKPD modeling would benefit the research community.

Purpose of the Study:

• To present PhysiPKPD, an open-source package for the PhysiCell simulator.
• To enable the inclusion of PKPD into PhysiCell-based models of biological tissue.
• To provide a standardized and flexible framework for PKPD modeling in silico.

Main Methods:

• Development of an open-source package named PhysiPKPD.
• Integration of PKPD modeling capabilities into the PhysiCell simulation platform.
• Utilizing a physics-based cell simulation approach.

Main Results:

• PhysiPKPD successfully allows users to incorporate PKPD into their PhysiCell models.
• The package provides a standardized and flexible framework for PKPD analysis.
• The open-source nature enhances accessibility and communicability within the research community.

Conclusions:

• PhysiPKPD enhances the capabilities of the PhysiCell simulator for modeling molecular therapies.
• The package facilitates more accurate and comprehensive in silico studies of biological tissues.
• PhysiPKPD is a valuable tool for researchers in mathematical biology and computational pharmacology.