Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Single wavelength, dual temporal offset module for AOSLO systems.

Biomedical optics express·2026
Same author

Revealing the benefit of eye motion for acuity under emulated cone loss.

bioRxiv : the preprint server for biology·2026
Same author

Focusing on color: How the eye chooses which wavelength to see best.

Science advances·2026
Same author

Physiological basis of resolution acuity in vision.

Nature communications·2026
Same author

Roadmap on advances in visual and physiological optics.

Journal of optics (2010)·2025
Same author

Longitudinal High-Resolution Imaging of Retinal Sequelae of a Choroidal Nevus.

Diagnostics (Basel, Switzerland)·2025

Related Experiment Video

Updated: Aug 6, 2025

Multimodal Volumetric Retinal Imaging by Oblique Scanning Laser Ophthalmoscopy oSLO and Optical Coherence Tomography OCT
12:22

Multimodal Volumetric Retinal Imaging by Oblique Scanning Laser Ophthalmoscopy oSLO and Optical Coherence Tomography OCT

Published on: August 4, 2018

8.6K

Evolution of adaptive optics retinal imaging [Invited].

David R Williams1, Stephen A Burns2, Donald T Miller2

  • 1The Institute of Optics and the Center for Visual Science, University of Rochester, Rochester NY, USA.

Biomedical Optics Express
|March 23, 2023
PubMed
Summary
This summary is machine-generated.

Adaptive optics (AO) in ophthalmoscopes has revolutionized retinal imaging over 25 years, enabling cellular-level visualization. This technology provides new tools for studying retinal structure and function in living eyes.

More Related Videos

Bringing the Visible Universe into Focus with Robo-AO
10:35

Bringing the Visible Universe into Focus with Robo-AO

Published on: February 12, 2013

19.5K
Integrated Photoacoustic Ophthalmoscopy and Spectral-domain Optical Coherence Tomography
11:21

Integrated Photoacoustic Ophthalmoscopy and Spectral-domain Optical Coherence Tomography

Published on: January 15, 2013

11.6K

Related Experiment Videos

Last Updated: Aug 6, 2025

Multimodal Volumetric Retinal Imaging by Oblique Scanning Laser Ophthalmoscopy oSLO and Optical Coherence Tomography OCT
12:22

Multimodal Volumetric Retinal Imaging by Oblique Scanning Laser Ophthalmoscopy oSLO and Optical Coherence Tomography OCT

Published on: August 4, 2018

8.6K
Bringing the Visible Universe into Focus with Robo-AO
10:35

Bringing the Visible Universe into Focus with Robo-AO

Published on: February 12, 2013

19.5K
Integrated Photoacoustic Ophthalmoscopy and Spectral-domain Optical Coherence Tomography
11:21

Integrated Photoacoustic Ophthalmoscopy and Spectral-domain Optical Coherence Tomography

Published on: January 15, 2013

11.6K

Area of Science:

  • Ophthalmology
  • Biomedical Optics
  • Retinal Imaging Technology

Background:

  • Adaptive optics (AO) integration into ophthalmoscopes began 25 years ago.
  • This innovation significantly improved the ability to image the retina at cellular resolution in vivo.
  • Significant advancements have been made in retinal imaging technology since AO's inception.

Purpose of the Study:

  • To review the progress of adaptive optics in ophthalmoscopy.
  • To detail technological advancements and their impact on retinal imaging.
  • To highlight scientific discoveries enabled by AO-enhanced retinal imaging.

Main Methods:

  • Comprehensive tabulation of adaptive optics (AO) research papers in retinal imaging.
  • Description of technological advances, including combinations with other imaging modalities (confocal, fluorescence, phase contrast, OCT).
  • Analysis of scientific discoveries resulting from AO applications in the living eye.

Main Results:

  • Adaptive optics enables cellular-scale imaging of the living retina.
  • Combined AO techniques have led to detailed topographical maps of the cone mosaic.
  • Sensitive measurements of optical and structural photoreceptor changes in response to light are now possible.

Conclusions:

  • Adaptive optics has transformed in vivo retinal imaging capabilities.
  • Continued technological evolution promises enhanced resolution and control for monitoring retinal structure and function.
  • Future applications will expand the array of tools for retinal research and clinical monitoring.