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Effects of Ureaplasma urealyticum infection on semen quality and sperm morphology

Fu Xianchun1, Fang Jun1, Dai Zhijun1

  • 1Centre for Reproductive Medicine, Affiliated Maternity and Child Health Hospital of Anhui Medical University, Anhui Province Maternity and Child Health Hospital, Hefei, Anhui, China.

Frontiers in Endocrinology
|March 23, 2023
PubMed
Abstract

Insights

Ureaplasma urealyticum infection in males is linked to reduced sperm concentration, motility, and normal morphology. Early detection is crucial for addressing male infertility concerns.

Area of Science:

  • Reproductive Medicine
  • Microbiology
  • Andrology

Background:

  • Ureaplasma urealyticum (U. urealyticum) infection is a known factor impacting male fertility.
  • The specific effects of U. urealyticum on semen quality and sperm morphology require further clarification.

Purpose of the Study:

  • To investigate the association between U. urealyticum infection and semen quality parameters.
  • To determine the relationship between U. urealyticum infection and sperm morphology in males.

Main Methods:

  • A cross-sectional study involving 1064 males aged 22-30 years.
  • Semen analysis performed according to World Health Organization guidelines.
  • Statistical analysis using general linear models to assess associations.

Main Results:

  • U. urealyticum infection was significantly associated with lower sperm concentrations (p<0.001).
  • A reduced ratio of anterograde motile spermatozoa was observed in infected males (p<0.001).
  • Semen cultures positive for U. urealyticum showed significantly lower normal sperm morphology rates (p<0.001).

Conclusions:

  • U. urealyticum infection negatively impacts key semen parameters, including sperm concentration, motility, and morphology.
  • Routine investigation for U. urealyticum is recommended in the clinical evaluation of male infertility.
Keywords:
Ureaplasma urealyticuminfertile menmale genitourinary infectionsemen qualitysperm morphology

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