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[GLP-1 and GIP receptor agonists: emerging therapies for obesity]

Dionysios Chartoumpekis1, Lucie Favre1

  • 1Service d'endocrinologie, diabétologie et métabolisme, Département de médecine, Centre hospitalier universitaire vaudois, 1011 Lausanne.

Revue Medicale Suisse
|March 23, 2023
PubMed

Insights

New obesity treatments targeting appetite regulation, like GLP-1 and dual GIP/GLP-1 therapies, offer significant weight loss beyond surgery. These advancements provide hope for managing this chronic metabolic disease.

Area of Science:

  • Endocrinology
  • Metabolic Diseases
  • Pharmacology

Context:

  • Obesity is a complex metabolic disease with severe health consequences.
  • Bariatric surgery was the primary method for substantial, lasting weight reduction.
  • Advances in understanding appetite regulation have spurred novel therapeutic development.

Purpose:

  • To summarize the mechanisms of action for new obesity medications.
  • To review clinical data supporting the efficacy of these treatments.
  • To highlight the role of incretin-based therapies in weight management.

Summary:

  • Glucagon-like peptide-1 (GLP-1) receptor agonists are established obesity treatments.
  • Dual therapies combining GLP-1 and glucose-dependent insulinotropic polypeptide (GIP) analogues show enhanced weight loss.
  • These agents target the endocrine regulation of appetite for metabolic control.

Impact:

  • Provides an overview of emerging pharmacological treatments for obesity.
  • Supports the clinical use of incretin mimetics for significant weight reduction.
  • Offers alternatives for patients seeking alternatives or adjuncts to bariatric surgery.

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