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Updated: Aug 17, 2026

An Intact Pericardium Ischemic Rodent Model
Published on: September 2, 2021
[Current problems of the pathological anatomy of ischemic (coronary) heart disease]
Insights
This review highlights how coronary arterial atherosclerosis develops from childhood, leading to thrombosis and myocardial infarction. It details the complications of different types of heart attacks.
Area of Science:
- Cardiovascular Science
- Pathology
- Epidemiology
Context:
- Atherosclerosis is a progressive disease starting in childhood.
- Coronary arterial thrombosis is a primary cause of myocardial infarction.
- Eccentric atherosclerotic plaques increase coronary artery spasm risk.
Purpose:
- To review the development of coronary arterial atherosclerosis from childhood.
- To demonstrate the link between coronary arterial thrombosis and myocardial infarction.
- To describe infarction types and complications.
Summary:
- The review examines the pathogenesis of coronary arterial atherosclerosis, emphasizing its childhood origins.
- It highlights the role of coronary arterial thrombosis in myocardial infarction and the association with atherosclerotic plaques and arterial spasm.
- The study also presents data on the course and complications of various myocardial infarction presentations, including incomplete, stable, and unstable forms.
Impact:
- Provides a comprehensive overview of coronary atherosclerosis development and its link to myocardial infarction.
- Informs understanding of infarction complications and different clinical presentations.
- Contributes to the knowledge base for cardiovascular disease research and prevention strategies.
Abstract:
Original and reported data are reviewed with respect to the development, from childhood onwards, of coronary arterial atherosclerosis. The leading contribution of coronary arterial thrombosis to myocardial infarction is demonstrated, as is high incidence of excentric atherosclerotic patches in coronary arteries, which are prone to spasm in the presence of such patches; the course and complications of left ventricular and right atrial or right ventricular infarction are described. Data on "incomplete", stable and unstable myocardial infarction are presented.
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