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Alpha-ketoglutaric acid based polymeric particles for cutaneous wound healing
Madhan M C S Jaggarapu1, Deepanjan Ghosh2, Tyler Johnston3
1Chemical Engineering, School for the Engineering of Matter, Transport, and Energy, Arizona State University, Tempe, Arizona, 85281, USA.
Journal of Biomedical Materials Research. Part A
|March 23, 2023
Summary
Polyesters of alpha-ketoglutarate (paKG) release alpha-ketoglutarate (aKG) to accelerate wound healing. These paKG microparticles promote faster skin repair in both lab tests and live mice, offering regenerative therapeutic potential.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Metabolomics
Background:
- Metabolites play crucial roles beyond energy metabolism, including signaling.
- Alpha-ketoglutarate (aKG) is a key metabolite with potential therapeutic applications.
Purpose of the Study:
- To synthesize and characterize polyesters of alpha-ketoglutarate (paKG).
- To investigate the wound healing potential of paKG-releasing microparticles.
Main Methods:
- Synthesis of paKG by reacting aKG with aliphatic diols.
- Fabrication of paKG microparticles using an emulsion-evaporation technique.
- In vitro scratch assay using keratinocytes.
- In vivo excisional wound model in mice.
Main Results:
- paKG polymers were successfully synthesized, releasing aKG in a sustained manner.
- paKG microparticles significantly accelerated keratinocyte wound closure in vitro.
- paKG microparticles demonstrated enhanced wound healing in a mouse model.
Conclusions:
- Sustained release of aKG from paKG microparticles promotes accelerated wound healing.
- paKG-based microparticles show promise as a regenerative therapeutic strategy for wound repair.
