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Modulating T Cell Phenotype and Function to Treat Hypertension

Daniel J Fehrenbach1, Bianca Nguyen2, Matthew R Alexander1,2,3

  • 1Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center (VUMC), Nashville, Tennessee.

Kidney360
|March 23, 2023
PubMed

Insights

Hypertension damages organs, and current blood pressure control is insufficient. This review explores T cells

Area of Science:

  • Immunology
  • Cardiovascular Science
  • Nephrology

Background:

  • Hypertension is a major global health issue, causing significant cardiovascular and renal damage.
  • Existing treatments for hypertension do not fully mitigate end-organ damage.
  • Immune system activation is linked to hypertension, yet targeted immunotherapies are lacking.

Approach:

  • This review examines the role of T cells in hypertension and associated end-organ damage.
  • It identifies potential therapeutic targets within T cell pathways.
  • The focus is on modulating T cell function without causing widespread immunosuppression.

Key Points:

  • T cells play a critical role in hypertension-related cardiovascular and renal damage.
  • Specific T cell subsets and their functions are implicated in hypertensive pathology.
  • Targeting T cell responses offers a novel therapeutic strategy for hypertension.

Conclusions:

  • Modulating T cell phenotype and function presents a promising avenue for novel hypertension therapies.
  • Targeted immunomodulation could improve outcomes in hypertensive patients by protecting end organs.
  • Further research into T cell-specific targets is warranted to develop effective treatments.

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