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Updated: Aug 6, 2025

Impact of High-intensity Interval Exercise and Moderate-Intensity Continuous Exercise on the Cardiac Troponin T Level at an Early Stage of Training
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Impact of High-intensity Interval Exercise and Moderate-Intensity Continuous Exercise on the Cardiac Troponin T Level at an Early Stage of Training

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Can high-sensitive troponin levels within the normal range predict positivity in treadmill test?

Mustafa Yilmaz1, Adem Atici2, Mehmet Rasih Sonsöz3

  • 1Cardiology Department, Bağcilar Medipol Mega University Hospital.

Coronary Artery Disease
|March 23, 2023
PubMed

Insights

High levels of high-sensitivity troponin T (hsTnT) effectively predict positive treadmill tests in patients with suspected stable ischemic heart disease (SIHD). Measuring hsTnT before the test improves diagnostic accuracy and is a cost-effective method.

Area of Science:

  • Cardiology
  • Diagnostic Medicine
  • Biomarker Research

Background:

  • Stable ischemic heart disease (SIHD) diagnosis often relies on treadmill testing.
  • Predictive biomarkers for treadmill test positivity in SIHD are crucial for early diagnosis.

Purpose of the Study:

  • To investigate if high-sensitivity troponin T (hsTnT) levels predict a positive treadmill test in patients with suspected SIHD.
  • To assess the utility of hsTnT as a pre-test predictor for SIHD.

Main Methods:

  • 366 patients with suspected SIHD underwent treadmill testing (Bruce protocol).
  • Serum hsTnT levels were measured before the treadmill test.
  • Binary logistic regression and ROC curve analysis were used to evaluate predictors.

Main Results:

  • 97 out of 366 patients had positive treadmill tests.
  • Significantly higher hsTnT levels were observed in patients with positive treadmill tests.
  • hsTnT, pretest probability, METs, THR, and DTS were independent predictors of a positive treadmill test (AUC: 0.945).

Conclusions:

  • Elevated pretest hsTnT levels are significant predictors of a positive treadmill test in suspected SIHD.
  • Incorporating hsTnT measurements can enhance the sensitivity and specificity of treadmill tests.
  • hsTnT measurement is a cost-effective and accessible tool for pre-treadmill assessment in SIHD.
Abstract

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