Can high-sensitive troponin levels within the normal range predict positivity in treadmill test?
Mustafa Yilmaz1, Adem Atici2, Mehmet Rasih Sonsöz3
1Cardiology Department, Bağcilar Medipol Mega University Hospital.
Coronary Artery Disease
|March 23, 2023
Summary
High levels of high-sensitivity troponin T (hsTnT) effectively predict positive treadmill tests in patients with suspected stable ischemic heart disease (SIHD). Measuring hsTnT before the test improves diagnostic accuracy and is a cost-effective method.
Area of Science:
- Cardiology
- Diagnostic Medicine
- Biomarker Research
Background:
- Stable ischemic heart disease (SIHD) diagnosis often relies on treadmill testing.
- Predictive biomarkers for treadmill test positivity in SIHD are crucial for early diagnosis.
Purpose of the Study:
- To investigate if high-sensitivity troponin T (hsTnT) levels predict a positive treadmill test in patients with suspected SIHD.
- To assess the utility of hsTnT as a pre-test predictor for SIHD.
Main Methods:
- 366 patients with suspected SIHD underwent treadmill testing (Bruce protocol).
- Serum hsTnT levels were measured before the treadmill test.
- Binary logistic regression and ROC curve analysis were used to evaluate predictors.
Main Results:
- 97 out of 366 patients had positive treadmill tests.
- Significantly higher hsTnT levels were observed in patients with positive treadmill tests.
- hsTnT, pretest probability, METs, THR, and DTS were independent predictors of a positive treadmill test (AUC: 0.945).
Conclusions:
- Elevated pretest hsTnT levels are significant predictors of a positive treadmill test in suspected SIHD.
- Incorporating hsTnT measurements can enhance the sensitivity and specificity of treadmill tests.
- hsTnT measurement is a cost-effective and accessible tool for pre-treadmill assessment in SIHD.
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