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Cognitive games in the dreaMS app show moderate-strong correlations with standard tests for people with MS (pwMS). These enjoyable and meaningful games may help monitor cognitive changes over time.

Keywords:
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Area of Science:

  • Neurology
  • Digital Health
  • Cognitive Science

Background:

  • Cognitive impairment affects up to 70% of people with MS (pwMS), significantly impacting quality of life and work capacity.
  • The dreaMS smartphone app is being developed to monitor MS disease activity and progression.
  • Assessing the feasibility and acceptance of cognitive games as tools for evaluating cognitive domains is crucial.

Purpose of the Study:

  • To evaluate the feasibility and acceptance of using cognitive games within the dreaMS app for assessing cognitive domains in people with MS.
  • To determine the correlation between cognitive game performance and established neuropsychological tests.
  • To assess user perception of the cognitive games' enjoyment and meaningfulness.

Main Methods:

  • Ten cognitive games were integrated into the dreaMS app.
  • Participants played games twice weekly for five weeks, alongside standard neuropsychological tests.
  • User acceptance was measured using a Likert-scale questionnaire, and game performance was correlated with reference tests (Spearman's rho).

Main Results:

  • Moderate-to-strong correlations (|rs|=0.34–0.77) were found between most game performances and reference tests.
  • Cognitive performance improved in both people with MS and healthy controls over the five-week period.
  • Games received high average ratings for overall impression (4.6) and meaningfulness (4.7), indicating good acceptance.

Conclusions:

  • Adaptive cognitive games demonstrate potential as valid measures for assessing cognitive domains in people with MS.
  • Observed practice effects suggest that game-derived measures can track cognitive changes over time.
  • The high acceptance and perceived meaningfulness of the games support their potential for long-term adherence in monitoring cognitive health.