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Related Concept Videos

Factors Affecting Illness01:18

Factors Affecting Illness

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When a person's physical, emotional, intellectual, social development or spiritual functioning is compromised, this deviation from a healthy normal state is called illness. Illness creates stress that in turn harms individuals. Irritation, anger, denial, hopelessness, and fear are behavioral and emotional changes an individual experiences in the phases of illness. A variety of factors influence a person's health and well-being.
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Related Experiment Video

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Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay
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Published on: September 9, 2012

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What is circulating factor disease and how is it currently explained?

Samantha Hayward1,2, Kevon Parmesar3, Moin A Saleem3

  • 1Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK. Samantha.Hayward@nhs.net.

Pediatric Nephrology (Berlin, Germany)
|March 23, 2023
PubMed
Summary
This summary is machine-generated.

Nephrotic syndrome can be driven by circulating factors, leading to disease recurrence after kidney transplants. Research is exploring multi-omic data to identify pre-transplant risk factors for this condition.

Keywords:
Circulating factor diseaseNephrotic syndromeSteroid sensitive nephrotic syndromeSteroid-resistant nephrotic syndromeTransplant recurrence

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Area of Science:

  • Nephrology
  • Immunology
  • Proteomics

Background:

  • Nephrotic syndrome (NS) is a complex kidney disorder characterized by proteinuria, hypoalbuminemia, and edema.
  • Circulating factors are implicated in a subset of NS cases, particularly those with post-transplant recurrence, termed circulating factor disease (CFD).

Purpose of the Study:

  • To review proposed circulating factors implicated in nephrotic syndrome.
  • To highlight the potential of multi-omic data analysis for identifying pre-transplant risk factors for CFD.

Main Methods:

  • Literature review of proposed circulating factors in NS.
  • Discussion of emerging bioinformatic approaches using multi-omic data.

Main Results:

  • Several circulating factors, including proteases (suPAR, Hx, CASK) and immune components (TNF-α, CD40, CLC-1), have been investigated as drivers of NS.
  • No definitive pre-transplant risk assessment for CFD currently exists.

Conclusions:

  • Understanding circulating factors is crucial for diagnosing and managing NS, especially CFD.
  • Multi-omic data analysis holds promise for developing predictive models for CFD risk before transplantation.