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Norethisterone contraceptive microspheres.

R Rivera1, G Alvarado, C Flores

  • 1Instituto de Investigacion Cientifica, Universidad Juarez del Estado de Durango, Avenida Universidad, Durango, Mexico.

Journal of Steroid Biochemistry
|January 1, 1987
PubMed
Summary

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This summary is machine-generated.

Norethisterone (NET) microcapsules demonstrated contraceptive effects by inhibiting ovulation and preventing pregnancy in women. Stable NET levels were observed, though menstrual cycle alterations were noted as side effects.

Area of Science:

  • Reproductive endocrinology
  • Pharmacology
  • Biomaterials science

Background:

  • Long-acting injectable contraceptives are crucial for family planning.
  • Polylactic and polyglycolic acid (PLGA) microcapsules offer a promising drug delivery system for sustained release.

Purpose of the Study:

  • To evaluate the contraceptive efficacy and safety of two NET formulations in PLGA microcapsules.
  • To assess the duration of contraceptive effect and circulating NET levels.

Main Methods:

  • Two groups of five women received 75 mg or 100 mg NET microcapsules for 90 days.
  • A separate group of 19 women received 200 mg NET microcapsules for 180 days.
  • Menstrual cycle patterns, ovulation, pregnancy, and NET levels were monitored.
Keywords:
AmericasBiodegradable Delivery SystemsClinical ResearchComparative StudiesContraceptionContraceptive Agents, Female--administraction and dosageContraceptive Agents, Female--side effectsContraceptive Agents, Progestin--administraction and dosageContraceptive Agents, Progestin--side effectsContraceptive Agents--administraction and dosageContraceptive Agents--side effectsContraceptive EffectivenessContraceptive MethodsDeveloping CountriesDiseasesFamily PlanningHealthLatin AmericaMenstruation DisordersMexicoNorethindrone--administraction and dosageNorethindrone--side effectsNorth AmericaPublic HealthResearch MethodologyResearch ReportSafetyStudies

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Main Results:

  • No pregnancies occurred in any participant.
  • Ovulation was inhibited in the majority of cases.
  • Stable circulating NET levels were maintained throughout the study periods.
  • Adverse effects included menstrual cycle alterations, such as spotting and amenorrhea.

Conclusions:

  • NET-loaded PLGA microcapsules show significant potential as long-acting contraceptives.
  • The formulations were effective in preventing pregnancy and inhibiting ovulation.
  • Further research is warranted to optimize formulations and manage side effects.