Related Experiment Videos
Effect of Brahmi Rasayan on the central nervous system
B Shukia1, N K Khanna, J L Godhwani
1Department of Pharmacology and Experimental Therapeutics, Dr. Sampurnanand Medical College, Jodhpur, Rajasthan, India.
Journal of Ethnopharmacology
|September 1, 1987
Summary
Brahmi Rasayan, an Ayurvedic preparation, demonstrated significant central nervous system effects in animal studies. It showed sedative properties, pain relief, and protection against seizures, suggesting a role for the GABA-ergic system.
Area of Science:
- Ayurvedic medicine
- Neuropharmacology
- Central Nervous System (CNS) research
Background:
- Ayurvedic preparations are traditional Indian medicines.
- Brahmi Rasayan is an Ayurvedic formulation.
- Its effects on the central nervous system require scientific investigation.
Purpose of the Study:
- To investigate the central nervous system (CNS) effects of Brahmi Rasayan.
- To evaluate its potential therapeutic actions.
Main Methods:
- Oral administration of Brahmi Rasayan to mice and rats at doses of 1-30 g/kg.
- Assessment of various neurological parameters including pentobarbitone hypnosis, motor coordination, and pain response.
- Evaluation of anticonvulsant and antipsychotic-like effects.
Main Results:
- Brahmi Rasayan exhibited significant sedative effects, prolonging pentobarbitone-induced hypnosis.
- Demonstrated antinociceptive (pain-relieving) properties.
- Offered protection against electroshock seizures and chemoconvulsions.
- Antagonized haloperidol-induced catalepsy and showed variable blockade of conditioned avoidance response.
Conclusions:
- The findings suggest Brahmi Rasayan possesses significant CNS activity.
- The observed effects, including sedation, analgesia, and anticonvulsant properties, indicate potential therapeutic benefits.
- The involvement of the GABA-ergic system is suggested in mediating these neuropharmacological effects.