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Joint effusions after kidney transplantation.

J D MacFarlane, R S Filo, K D Brandt

    Arthritis and Rheumatism
    |February 1, 1979
    PubMed
    Summary
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    Renal transplant patients may experience joint pain and knee effusions during corticosteroid dose reduction. These benign effusions are likely linked to high-dose oral corticosteroid therapy, not transplant complications.

    Area of Science:

    • Nephrology
    • Rheumatology
    • Transplant Medicine

    Background:

    • Renal transplantation is a common procedure for end-stage renal disease.
    • Corticosteroids are frequently used post-transplant but can have side effects.
    • Joint complications following transplantation require further investigation.

    Purpose of the Study:

    • To prospectively investigate the incidence and characteristics of joint disease in renal transplant recipients.
    • To determine the potential causes of joint effusions in this patient population.

    Main Methods:

    • Prospective study of 37 consecutive renal transplant recipients.
    • Monitoring for joint pain (arthralgias) and knee effusions.
    • Analysis of synovial fluid for cell counts and other parameters.

    Related Experiment Videos

  • Correlation with corticosteroid dosage, immunologic status, and other potential causes.

    • Main Results:

    • Six patients developed arthralgias during corticosteroid dose reduction.
    • Eleven patients (30%) developed knee effusions within 10 days post-transplant.
    • Synovial fluid analysis revealed benign, transudative effusions with low leukocyte counts.
    • Effusions did not correlate with rejection, crystal deposition, or avascular necrosis.

    Conclusions:

    • Benign knee effusions are a notable complication in renal transplant recipients.
    • High-dose oral corticosteroid therapy is a likely cause of these joint effusions.
    • These effusions appear unrelated to transplant rejection or other common causes.