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The Lung Microbiome in Carcinogenesis and Immunotherapy Treatment
Kathleen Kennedy1, Karam Khaddour1, Nithya Ramnath
1From the Department of Medicine, University of Illinois Chicago, Chicago, IL.
Cancer Journal (Sudbury, Mass.)
|March 23, 2023
Summary
The lung microbiome, alongside the gut microbiome, may predict responses to immune checkpoint inhibitors (ICIs) in lung cancer. Understanding these microbial communities could lead to better cancer treatments and improved patient outcomes.
Area of Science:
- Oncology
- Microbiology
- Immunology
Background:
- Lung cancer remains a leading cause of cancer mortality globally.
- Advances in immune checkpoint inhibitors (ICIs) have improved patient outcomes.
- Biomarkers are crucial for predicting ICI response and developing novel therapeutic strategies.
Approach:
- This review explores the role of the lung microbiome in lung cancer development and treatment.
- It examines current research on lung microbiome's influence on tumorigenesis and immunotherapy.
- The review synthesizes findings on host microbiomes beyond the gut in cancer contexts.
Key Points:
- The gut microbiome is an emerging predictive biomarker for ICI therapy in various cancers.
- The influence of other host microbiomes, particularly the lung microbiome, on tumorigenesis and ICI response requires further investigation.
- Research into the lung microbiome's function in health and disease is expanding.
Conclusions:
- The lung microbiome plays a significant role in lung cancer pathogenesis and response to immunotherapy.
- Further research into the lung microbiome could reveal new therapeutic targets to enhance ICI efficacy.
- Understanding the lung microbiome may improve treatment strategies and patient outcomes in lung cancer.
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